The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

2G12 is a broadly neutralizing human monoclonal antibody against human immunodeficiency virus type-1 (HIV-1) that has previously been shown to bind to a carbohydrate-dependent epitope on gp120. Here, site-directed mutagenesis and carbohydrate analysis were used to define further the 2G12 epitope. Ex...

Bibliografske podrobnosti
Main Authors:	Scanlan, C, Pantophlet, R, Wormald, M, Ollmann Saphire, E, Stanfield, R, Wilson, I, Katinger, H, Dwek, R, Rudd, P, Burton, DR
Format:	Journal article
Jezik:	English
Izdano:	2002

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