Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

BACKGROUND: Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an importan...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Khoo, J, Zhao, L, Alp, N, Bendall, J, Nicoli, T, Rockett, K, Wilkins, MR, Channon, K
التنسيق:	Journal article
اللغة:	English
منشور في:	2005

مواد مشابهة

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
حسب: Khoo, J, وآخرون
منشور في: (2004)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
حسب: Khoo, J, وآخرون
منشور في: (2005)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
حسب: Khoo, J, وآخرون
منشور في: (2004)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
حسب: Bendall, J, وآخرون
منشور في: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
حسب: Bendall, J, وآخرون
منشور في: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
حسب: Bendall, J, وآخرون
منشور في: (2004)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
حسب: Alp, N, وآخرون
منشور في: (2003)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
حسب: Khoo, J, وآخرون
منشور في: (2004)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
حسب: Chuaiphichai, S, وآخرون
منشور في: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
حسب: Chuaiphichai, S, وآخرون
منشور في: (2014)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
حسب: Bendall, J, وآخرون
منشور في: (2005)

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
حسب: Khoo, J, وآخرون
منشور في: (2004)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
حسب: Alp, N, وآخرون
منشور في: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
حسب: Chuaiphichai, S, وآخرون
منشور في: (2014)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
حسب: Alp, N, وآخرون
منشور في: (2003)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
حسب: Alp, N, وآخرون
منشور في: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
حسب: Cai, S, وآخرون
منشور في: (2005)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
حسب: Khoo, J, وآخرون
منشور في: (2005)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
حسب: Alp, N, وآخرون
منشور في: (2002)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
حسب: Cai, S, وآخرون
منشور في: (2004)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
حسب: Alp, N, وآخرون
منشور في: (2003)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
حسب: Ali, Z, وآخرون
منشور في: (2006)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
حسب: Khoo, J, وآخرون
منشور في: (2005)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
حسب: Alp, N, وآخرون
منشور في: (2003)

Endothelial cell tetrahydrobiopterin: going with the flow.
حسب: De Bono, J, وآخرون
منشور في: (2007)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
حسب: Alp, N, وآخرون
منشور في: (2004)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
حسب: Ali, Z, وآخرون
منشور في: (2007)

Tetrahydrobiopterin regulates vagal control of heart rate
حسب: Adlam, D, وآخرون
منشور في: (2005)

Tetrahydrobiopterin in cardiovascular health and disease.
حسب: Bendall, J, وآخرون
منشور في: (2014)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
حسب: Rinze, R, وآخرون
منشور في: (2008)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
حسب: Ali, Z, وآخرون
منشور في: (2011)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
حسب: Ali, Z, وآخرون
منشور في: (2008)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
حسب: Crabtree, M, وآخرون
منشور في: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
حسب: Crabtree, M, وآخرون
منشور في: (2011)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
حسب: Channon, K
منشور في: (2012)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
حسب: Channon, K
منشور في: (2004)

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
حسب: Chuaiphichai, S, وآخرون
منشور في: (2017)

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
حسب: Heales, S, وآخرون
منشور في: (2005)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
حسب: Ali, Z, وآخرون
منشور في: (2005)

A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance
حسب: Bailey, J, وآخرون
منشور في: (2017)