Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

BACKGROUND: Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an importan...

Bibliográfalaš dieđut
Váldodahkkit:	Khoo, J, Zhao, L, Alp, N, Bendall, J, Nicoli, T, Rockett, K, Wilkins, MR, Channon, K
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2005

Geahča maid

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
Dahkki: Khoo, J, et al.
Almmustuhtton: (2004)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
Dahkki: Khoo, J, et al.
Almmustuhtton: (2005)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
Dahkki: Khoo, J, et al.
Almmustuhtton: (2004)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
Dahkki: Bendall, J, et al.
Almmustuhtton: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
Dahkki: Bendall, J, et al.
Almmustuhtton: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
Dahkki: Bendall, J, et al.
Almmustuhtton: (2004)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
Dahkki: Alp, N, et al.
Almmustuhtton: (2003)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
Dahkki: Khoo, J, et al.
Almmustuhtton: (2004)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Dahkki: Chuaiphichai, S, et al.
Almmustuhtton: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
Dahkki: Chuaiphichai, S, et al.
Almmustuhtton: (2014)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
Dahkki: Bendall, J, et al.
Almmustuhtton: (2005)

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
Dahkki: Khoo, J, et al.
Almmustuhtton: (2004)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Dahkki: Alp, N, et al.
Almmustuhtton: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Dahkki: Chuaiphichai, S, et al.
Almmustuhtton: (2014)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
Dahkki: Alp, N, et al.
Almmustuhtton: (2003)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
Dahkki: Alp, N, et al.
Almmustuhtton: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
Dahkki: Cai, S, et al.
Almmustuhtton: (2005)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
Dahkki: Khoo, J, et al.
Almmustuhtton: (2005)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
Dahkki: Alp, N, et al.
Almmustuhtton: (2002)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
Dahkki: Cai, S, et al.
Almmustuhtton: (2004)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
Dahkki: Alp, N, et al.
Almmustuhtton: (2003)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
Dahkki: Ali, Z, et al.
Almmustuhtton: (2006)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
Dahkki: Khoo, J, et al.
Almmustuhtton: (2005)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
Dahkki: Alp, N, et al.
Almmustuhtton: (2003)

Endothelial cell tetrahydrobiopterin: going with the flow.
Dahkki: De Bono, J, et al.
Almmustuhtton: (2007)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
Dahkki: Alp, N, et al.
Almmustuhtton: (2004)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
Dahkki: Ali, Z, et al.
Almmustuhtton: (2007)

Tetrahydrobiopterin regulates vagal control of heart rate
Dahkki: Adlam, D, et al.
Almmustuhtton: (2005)

Tetrahydrobiopterin in cardiovascular health and disease.
Dahkki: Bendall, J, et al.
Almmustuhtton: (2014)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
Dahkki: Rinze, R, et al.
Almmustuhtton: (2008)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
Dahkki: Ali, Z, et al.
Almmustuhtton: (2011)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Dahkki: Ali, Z, et al.
Almmustuhtton: (2008)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Dahkki: Crabtree, M, et al.
Almmustuhtton: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
Dahkki: Crabtree, M, et al.
Almmustuhtton: (2011)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
Dahkki: Channon, K
Almmustuhtton: (2012)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
Dahkki: Channon, K
Almmustuhtton: (2004)

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
Dahkki: Chuaiphichai, S, et al.
Almmustuhtton: (2017)

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
Dahkki: Heales, S, et al.
Almmustuhtton: (2005)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
Dahkki: Ali, Z, et al.
Almmustuhtton: (2005)

A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance
Dahkki: Bailey, J, et al.
Almmustuhtton: (2017)