Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

Activating mutations in the genes encoding the ATP-sensitive potassium (K(ATP)) channel subunits Kir6.2 and SUR1 are a common cause of neonatal diabetes. Here, we analyse the molecular mechanism of action of the heterozygous mutation F132L, which lies in the first set of transmembrane helices (TMD0)...

詳細記述

書誌詳細
主要な著者: Proks, P, Shimomura, K, Craig, T, Girard, C, Ashcroft, F
フォーマット: Journal article
言語:English
出版事項: 2007