Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

Activating mutations in the genes encoding the ATP-sensitive potassium (K(ATP)) channel subunits Kir6.2 and SUR1 are a common cause of neonatal diabetes. Here, we analyse the molecular mechanism of action of the heterozygous mutation F132L, which lies in the first set of transmembrane helices (TMD0)...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Proks, P, Shimomura, K, Craig, T, Girard, C, Ashcroft, F
Format: Journal article
Język:English
Wydane: 2007