A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine.

A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine.

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Fixed-dose combination analgesics are used widely, and available both on prescription and over-the-counter. Combination drugs should provide more analgesia than with any single drug in the combination, but there is no evidence in humans about whether oral combinations have just additive effects, or...

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Main Authors:	Moore, R, Derry, C, Derry, S, Straube, S, McQuay, H
格式:	Journal article
语言:	English
出版:	2012

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