A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine.

Fixed-dose combination analgesics are used widely, and available both on prescription and over-the-counter. Combination drugs should provide more analgesia than with any single drug in the combination, but there is no evidence in humans about whether oral combinations have just additive effects, or...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Moore, R, Derry, C, Derry, S, Straube, S, McQuay, H
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2012