The role of protein structural analysis in the next generation sequencing era.
Proteins are macromolecules that serve a cell's myriad processes and functions in all living organisms via dynamic interactions with other proteins, small molecules and cellular components. Genetic variations in the protein-encoding regions of the human genome account for >85% of all kno...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797089097382100992 |
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| author | Yue, W Froese, D Brennan, P |
| author_facet | Yue, W Froese, D Brennan, P |
| author_sort | Yue, W |
| collection | OXFORD |
| description | Proteins are macromolecules that serve a cell's myriad processes and functions in all living organisms via dynamic interactions with other proteins, small molecules and cellular components. Genetic variations in the protein-encoding regions of the human genome account for >85% of all known Mendelian diseases, and play an influential role in shaping complex polygenic diseases. Proteins also serve as the predominant target class for the design of small molecule drugs to modulate their activity. Knowledge of the shape and form of proteins, by means of their three-dimensional structures, is therefore instrumental to understanding their roles in disease and their potentials for drug development. In this chapter we outline, with the wide readership of non-structural biologists in mind, the various experimental and computational methods available for protein structure determination. We summarize how the wealth of structure information, contributed to a large extent by the technological advances in structure determination to date, serves as a useful tool to decipher the molecular basis of genetic variations for disease characterization and diagnosis, particularly in the emerging era of genomic medicine, and becomes an integral component in the modern day approach towards rational drug development. |
| first_indexed | 2024-03-07T02:59:35Z |
| format | Journal article |
| id | oxford-uuid:b07fae8c-58bd-4404-b4df-30c480ddcdfa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:59:35Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:b07fae8c-58bd-4404-b4df-30c480ddcdfa2022-03-27T03:56:57ZThe role of protein structural analysis in the next generation sequencing era.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b07fae8c-58bd-4404-b4df-30c480ddcdfaEnglishSymplectic Elements at Oxford2014Yue, WFroese, DBrennan, PProteins are macromolecules that serve a cell's myriad processes and functions in all living organisms via dynamic interactions with other proteins, small molecules and cellular components. Genetic variations in the protein-encoding regions of the human genome account for >85% of all known Mendelian diseases, and play an influential role in shaping complex polygenic diseases. Proteins also serve as the predominant target class for the design of small molecule drugs to modulate their activity. Knowledge of the shape and form of proteins, by means of their three-dimensional structures, is therefore instrumental to understanding their roles in disease and their potentials for drug development. In this chapter we outline, with the wide readership of non-structural biologists in mind, the various experimental and computational methods available for protein structure determination. We summarize how the wealth of structure information, contributed to a large extent by the technological advances in structure determination to date, serves as a useful tool to decipher the molecular basis of genetic variations for disease characterization and diagnosis, particularly in the emerging era of genomic medicine, and becomes an integral component in the modern day approach towards rational drug development. |
| spellingShingle | Yue, W Froese, D Brennan, P The role of protein structural analysis in the next generation sequencing era. |
| title | The role of protein structural analysis in the next generation sequencing era. |
| title_full | The role of protein structural analysis in the next generation sequencing era. |
| title_fullStr | The role of protein structural analysis in the next generation sequencing era. |
| title_full_unstemmed | The role of protein structural analysis in the next generation sequencing era. |
| title_short | The role of protein structural analysis in the next generation sequencing era. |
| title_sort | role of protein structural analysis in the next generation sequencing era |
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