The Cell Physiology of Biphasic Insulin Secretion.

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of sec...

Полное описание

Библиографические подробности
Главные авторы: Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S
Формат: Journal article
Язык:English
Опубликовано: 2000
Описание
Итог:Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.