The Cell Physiology of Biphasic Insulin Secretion.

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of sec...

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Chi tiết về thư mục
Những tác giả chính: Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2000
Miêu tả
Tóm tắt:Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.