The Cell Physiology of Biphasic Insulin Secretion.
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of sec...
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2000
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| _version_ | 1826291480269946880 |
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| author | Rorsman, P Eliasson, L Renström, E Gromada, J Barg, S Göpel, S |
| author_facet | Rorsman, P Eliasson, L Renström, E Gromada, J Barg, S Göpel, S |
| author_sort | Rorsman, P |
| collection | OXFORD |
| description | Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes. |
| first_indexed | 2024-03-07T03:00:01Z |
| format | Journal article |
| id | oxford-uuid:b0a4f53f-4ee6-4f70-ac95-2e1a8ec03d6d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:00:01Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:b0a4f53f-4ee6-4f70-ac95-2e1a8ec03d6d2022-03-27T03:57:59ZThe Cell Physiology of Biphasic Insulin Secretion.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b0a4f53f-4ee6-4f70-ac95-2e1a8ec03d6dEnglishSymplectic Elements at Oxford2000Rorsman, PEliasson, LRenström, EGromada, JBarg, SGöpel, SGlucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes. |
| spellingShingle | Rorsman, P Eliasson, L Renström, E Gromada, J Barg, S Göpel, S The Cell Physiology of Biphasic Insulin Secretion. |
| title | The Cell Physiology of Biphasic Insulin Secretion. |
| title_full | The Cell Physiology of Biphasic Insulin Secretion. |
| title_fullStr | The Cell Physiology of Biphasic Insulin Secretion. |
| title_full_unstemmed | The Cell Physiology of Biphasic Insulin Secretion. |
| title_short | The Cell Physiology of Biphasic Insulin Secretion. |
| title_sort | cell physiology of biphasic insulin secretion |
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