The Cell Physiology of Biphasic Insulin Secretion.

The Cell Physiology of Biphasic Insulin Secretion.

Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of sec...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2000

Παρόμοια τεκμήρια

Exocytosis depends on granular chloride fluxes regulated by a sulfonylurea receptor-like protein in insulin-secreting B-cells
ανά: Barg, S, κ.ά.
Έκδοση: (1999)

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
ανά: Barg, S, κ.ά.
Έκδοση: (2002)

Fast exocytosis with few Ca2+-channels by economical use of Ca2+ in insulin-secreting pancreatic B-cells
ανά: Barg, S, κ.ά.
Έκδοση: (2000)

Somatostatin but not insulin is an important paracrine regulator of glucagon secretion in rat A-cells
ανά: Renstrom, E, κ.ά.
Έκδοση: (1997)

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
ανά: Barg, S, κ.ά.
Έκδοση: (2000)

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
ανά: Olofsson, C, κ.ά.
Έκδοση: (2002)

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.
ανά: Gromada, J, κ.ά.
Έκδοση: (1997)

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.
ανά: Barg, S, κ.ά.
Έκδοση: (2001)

Components of insulin secretion: lessons to be learnt from capacitance.
ανά: Rorsman, P, κ.ά.
Έκδοση: (1997)

Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.
ανά: Göpel, S, κ.ά.
Έκδοση: (1999)

Activation of Ca2+-dependent K+ channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells
ανά: Gopel, S, κ.ά.
Έκδοση: (1999)

Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.
ανά: Göpel, S, κ.ά.
Έκδοση: (2000)

CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.
ανά: Gromada, J, κ.ά.
Έκδοση: (1999)

Ion channels, electrical activity and insulin secretion.
ανά: Rorsman, P, κ.ά.
Έκδοση: (1994)

Biphasic nature of glucose-induced insulin secretion is independent on energy metabolism
ανά: Tarasov, A, κ.ά.
Έκδοση: (2014)

Identification and characterization of single glucagon-secreting A-cells in a standard mouse islet preparation
ανά: Barg, S, κ.ά.
Έκδοση: (1999)

Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.
ανά: Göpel, S, κ.ά.
Έκδοση: (2000)

Activation of Ca2+-activated K+-conductance terminates the burst of action potentials in insulin-secreting pancreatic B-cells
ανά: Gopel, S, κ.ά.
Έκδοση: (1998)

Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.
ανά: Gromada, J, κ.ά.
Έκδοση: (1997)

Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.
ανά: Kanno, T, κ.ά.
Έκδοση: (2004)

[Electrophysiological studies of insulin secretion, physiology and pathophysiology]
ανά: Rorsman, P
Έκδοση: (1997)

Insulin secretion: a high-affinity Ca2+ sensor after all?
ανά: Barg, S, κ.ά.
Έκδοση: (2004)

COOLING INHIBITS INSULIN-SECRETION BY SUPPRESSION OF GRANULE MOBILIZATION
ανά: Eliasson, L, κ.ά.
Έκδοση: (1995)

Regulated exocytosis of single insulin granules and synaptic-like vesicles in membrane patches of insulin secreting cells
ανά: Macdonald, P, κ.ά.
Έκδοση: (2004)

Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms.
ανά: Gromada, J, κ.ά.
Έκδοση: (1996)

Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells.
ανά: Gromada, J, κ.ά.
Έκδοση: (1996)

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
ανά: Gromada, J, κ.ά.
Έκδοση: (1995)

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.
ανά: Barg, S, κ.ά.
Έκδοση: (2001)

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.
ανά: Gromada, J, κ.ά.
Έκδοση: (2004)

Selective nucleotide-release from dense-core granules in insulin-secreting cells.
ανά: Obermüller, S, κ.ά.
Έκδοση: (2005)

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
ανά: MacDonald, P, κ.ά.
Έκδοση: (2005)

Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.
ανά: Renström, E, κ.ά.
Έκδοση: (1996)

DIRECT EVIDENCE FOR THE EXISTENCE OF HOT-SPOTS OF SECRETION IN MOUSE PANCREATIC BETA-CELLS
ανά: Bokvist, K, κ.ά.
Έκδοση: (1994)

The stimulatory action of tolbutamide on Ca2+-dependent exocytosis is mediated by a 65-kDa mdr-like P-glycoprotein and ClC3Cl(-)-channels in granule membranes of insulin secreting B-cells.
ανά: Thevenod, F, κ.ά.
Έκδοση: (2000)

Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.
ανά: Renström, E, κ.ά.
Έκδοση: (2002)

Adrenaline stimulates secretion in rat pancreatic alpha-cells by PKA-dependent acceleration of Ca2+ influx through 1-type Ca2+- channels
ανά: Gromada, J, κ.ά.
Έκδοση: (1996)

Novel aspects of the molecular mechanisms controlling insulin secretion.
ανά: Eliasson, L, κ.ά.
Έκδοση: (2008)

Acetylcholine stimulates exocytosis by acceleration of granula mobilisation in mouse pancreatic B-cells
ανά: Gromada, J, κ.ά.
Έκδοση: (1998)

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
ανά: Ding, W, κ.ά.
Έκδοση: (1997)

Biphasic voltage‐dependent inactivation of human NaV1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin‐secreting cells
ανά: Godazgar, M, κ.ά.
Έκδοση: (2018)