The Cell Physiology of Biphasic Insulin Secretion.
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of sec...
Main Authors: | Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S |
---|---|
פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2000
|
פריטים דומים
-
Exocytosis depends on granular chloride fluxes regulated by a sulfonylurea receptor-like protein in insulin-secreting B-cells
מאת: Barg, S, et al.
יצא לאור: (1999) -
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
מאת: Barg, S, et al.
יצא לאור: (2002) -
Fast exocytosis with few Ca2+-channels by economical use of Ca2+ in insulin-secreting pancreatic B-cells
מאת: Barg, S, et al.
יצא לאור: (2000) -
Somatostatin but not insulin is an important paracrine regulator of glucagon secretion in rat A-cells
מאת: Renstrom, E, et al.
יצא לאור: (1997) -
Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
מאת: Barg, S, et al.
יצא לאור: (2000)