The Cell Physiology of Biphasic Insulin Secretion.
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of sec...
Հիմնական հեղինակներ: | Rorsman, P, Eliasson, L, Renström, E, Gromada, J, Barg, S, Göpel, S |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2000
|
Նմանատիպ նյութեր
-
Exocytosis depends on granular chloride fluxes regulated by a sulfonylurea receptor-like protein in insulin-secreting B-cells
: Barg, S, և այլն
Հրապարակվել է: (1999) -
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
: Barg, S, և այլն
Հրապարակվել է: (2002) -
Fast exocytosis with few Ca2+-channels by economical use of Ca2+ in insulin-secreting pancreatic B-cells
: Barg, S, և այլն
Հրապարակվել է: (2000) -
Somatostatin but not insulin is an important paracrine regulator of glucagon secretion in rat A-cells
: Renstrom, E, և այլն
Հրապարակվել է: (1997) -
Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
: Barg, S, և այլն
Հրապարակվել է: (2000)