The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats.
Taxanes, including docetaxel (DOCE), are severely neurotoxic, causing disabling peripheral neuropathy. Co-treatment with neuroprotective agents has been proposed to prevent or reverse this. Besides its hemopoietic effects, erythropoietin (EPO) has neuroprotective and neurotrophic properties and when...
Hlavní autoři: | Cervellini, I, Bello, E, Frapolli, R, Porretta-Serapiglia, C, Oggioni, N, Canta, A, Lombardi, R, Camozzi, F, Roglio, I, Melcangi, R, D'incalci, M, Lauria, G, Ghezzi, P, Cavaletti, G, Bianchi, R |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
2010
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