Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.

BACKGROUND: Antiglobulin responses are a significant limitation to the repeated use of murine monoclonal antibodies for treatment of transplant rejection. It is hoped that these might be largely overcome by using antibodies genetically engineered to resemble human antibodies. METHODS: We have compa...

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Hlavní autoři: Rebello, P, Hale, G, Friend, P, Cobbold, S, Waldmann, H
Médium: Journal article
Jazyk:English
Vydáno: 1999