Disability as an outcome in MS clinical trials.

Disability as an outcome in MS clinical trials.

BACKGROUND: Inferences about long-term effects of therapies in multiple sclerosis (MS) have been based on surrogate markers studied in short-term trials. Preventing progressive disability is the key therapeutic goal but there remains no validated definition for its measurement in a trial context. M...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Ebers, G, Heigenhauser, L, Daumer, M, Lederer, C, Noseworthy, J
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2008

समान संसाधन

Measuring disability progression in MS
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Combined MRI lesions and relapses as a surrogate for disability in MS.
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Interrater variability with the Expanded Disability Status Scale (EDSS) and Functional Systems (FS) in a multiple sclerosis clinical trial. The Canadian Cooperation MS Study Group.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

Natural history of MS.
द्वारा: Ebers, G, और अन्य
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Surrogate endpoints for EDSS worsening in multiple sclerosis: a meta-analytic approach: measuring disability in relapsing-remitting MS.
द्वारा: Ebers, G, और अन्य
प्रकाशित: (2011)

MRI as an outcome in multiple sclerosis clinical trials.
द्वारा: Daumer, M, और अन्य
प्रकाशित: (2009)

MRI ASANOUTCOMEIN MULTIPLE SCLEROSIS CLINICAL TRIALS Reply
द्वारा: Ebers, G, और अन्य
प्रकाशित: (2009)

INTERRATER VARIABILITY WITH THE EXPANDED DISABILITY STATUS SCALE (EDSS) AND FUNCTIONAL-SYSTEMS (FS) IN A MULTIPLE-SCLEROSIS CLINICAL-TRIAL
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

Plasma exchange for MS.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

PLASMA-EXCHANGE FOR MS
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

Cyclophosphamide and MS.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1994)

CYCLOPHOSPHAMIDE AND MS
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1994)

MS REFERENDUM - REPLY
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

Erratum: Plasma exchange for MS (Neurology (1990) 40 (864-866))
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

Immunotherapy for MS: clinical aspects and trials.
द्वारा: Ebers, G, और अन्य
प्रकाशित: (1995)

IMMUNOTHERAPY FOR MS - CLINICAL ASPECTS AND TRIALS
द्वारा: Ebers, G, और अन्य
प्रकाशित: (1995)

MULTIPLE-SCLEROSIS (MS) PRESENTING IN PATIENTS OVER 50 YEARS OF AGE
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1981)

Age and disability accumulation in multiple sclerosis.
द्वारा: Scalfari, A, और अन्य
प्रकाशित: (2011)

Therapeutic trials in multiple sclerosis.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1984)

A referendum on clinical trial research in multiple sclerosis: the opinion of the participants at the Jekyll Island workshop.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1989)

The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.
द्वारा: Weinshenker, BG, और अन्य
प्रकाशित: (1989)

The relationship of clinically isolated syndromes and MS
द्वारा: Ebers, G
प्रकाशित: (2009)

ACCEPTANCE OF PLACEBO-CONTROL TRIAL DESIGN BY PROGRESSIVE MULTIPLE-SCLEROSIS PATIENTS
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1989)

Reply from the authors
द्वारा: Ebers, G, और अन्य
प्रकाशित: (2009)

Acceptance of placebo-control trial design by progressive multiple sclerosis patients. The Canadian Cooperative Multiple Sclerosis Study Group.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1989)

Inter-rater variability on multiple sclerosis disability scales in a blinded, prospective clinical trial
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1989)

The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1994)

The natural history of multiple sclerosis: a geographically based study 10: relapses and long-term disability.
द्वारा: Scalfari, A, और अन्य
प्रकाशित: (2010)

The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. 1994 [classical article]
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (2001)

The natural history of multiple sclerosis: a geographically based study. 4. Applications to planning and interpretation of clinical therapeutic trials.
द्वारा: Weinshenker, BG, और अन्य
प्रकाशित: (1991)

Early relapses, onset of progression, and late outcome in multiple sclerosis.
द्वारा: Scalfari, A, और अन्य
प्रकाशित: (2013)

Oligoclonal banding in MS.
द्वारा: Ebers, G
प्रकाशित: (1984)

MS and autoimmune disorders.
द्वारा: Ebers, G
प्रकाशित: (2009)

An open-trial evaluation of mitoxantrone in the treatment of progressive MS.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1993)

Primary biliary cirrhosis and multiple sclerosis.
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1989)

ACTIVE RELAPSING AND PROGRESSIVE MULTIPLE-SCLEROSIS PATIENTS HAVE SIMILAR MAGNETIC-RESONANCE-IMAGING BEHAVIOR - IMPLICATIONS FOR CLINICAL-TRIAL DESIGN
द्वारा: Noseworthy, J, और अन्य
प्रकाशित: (1990)

A twin consensus in MS.
द्वारा: Ebers, G
प्रकाशित: (2005)

MS - EVIDENCE FOR AN ENVIRONMENTAL-EFFECT
द्वारा: Cripps, J, और अन्य
प्रकाशित: (1982)

Familial studies in MS: genes and environment
द्वारा: Ebers, G
प्रकाशित: (2009)

Development and validation of a new method to measure walking speed in free-living environments using the actibelt® platform.
द्वारा: Michaela Schimpl, और अन्य
प्रकाशित: (2011-01-01)