Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides
Single enantiomer molecules are important for the pharmaceutical and agrochemical industries and increasingly so in materials science. Most strategies to obtain enantiomerically enriched molecules rely on either generating new stereogenic centres from prochiral substrates or resolving racemic mixtur...
| Main Authors: | , , , |
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| Format: | Journal article |
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Royal Society of Chemistry
2017
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| _version_ | 1797089155664052224 |
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| author | Schafer, P Sidera, M Palacin, T Fletcher, S |
| author_facet | Schafer, P Sidera, M Palacin, T Fletcher, S |
| author_sort | Schafer, P |
| collection | OXFORD |
| description | Single enantiomer molecules are important for the pharmaceutical and agrochemical industries and increasingly so in materials science. Most strategies to obtain enantiomerically enriched molecules rely on either generating new stereogenic centres from prochiral substrates or resolving racemic mixtures of enantiomers. Dynamic asymmetric processes are poweful methods that use racemic mixtures of chiral substrates as starting material. This Feature Article focuses on asymmetric additions to racemic substrates using non-stabilized sp2- and sp3-hybridized nucleophiles. These reactions bear considerable resemblance to traditional sp2–sp2 cross-coupling reactions in terms of the starting materials used and the products obtained, but the reaction mechanisms are necessarily different. |
| first_indexed | 2024-03-07T03:00:22Z |
| format | Journal article |
| id | oxford-uuid:b0c26e90-6ec4-4d47-9607-e69809413463 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T03:00:22Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:b0c26e90-6ec4-4d47-9607-e698094134632022-03-27T03:58:48ZAsymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halidesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b0c26e90-6ec4-4d47-9607-e69809413463Symplectic Elements at OxfordRoyal Society of Chemistry2017Schafer, PSidera, MPalacin, TFletcher, SSingle enantiomer molecules are important for the pharmaceutical and agrochemical industries and increasingly so in materials science. Most strategies to obtain enantiomerically enriched molecules rely on either generating new stereogenic centres from prochiral substrates or resolving racemic mixtures of enantiomers. Dynamic asymmetric processes are poweful methods that use racemic mixtures of chiral substrates as starting material. This Feature Article focuses on asymmetric additions to racemic substrates using non-stabilized sp2- and sp3-hybridized nucleophiles. These reactions bear considerable resemblance to traditional sp2–sp2 cross-coupling reactions in terms of the starting materials used and the products obtained, but the reaction mechanisms are necessarily different. |
| spellingShingle | Schafer, P Sidera, M Palacin, T Fletcher, S Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides |
| title | Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides |
| title_full | Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides |
| title_fullStr | Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides |
| title_full_unstemmed | Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides |
| title_short | Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides |
| title_sort | asymmetric cross coupling of alkyl alkenyl and hetero aryl nucleophiles with racemic allyl halides |
| work_keys_str_mv | AT schaferp asymmetriccrosscouplingofalkylalkenylandheteroarylnucleophileswithracemicallylhalides AT sideram asymmetriccrosscouplingofalkylalkenylandheteroarylnucleophileswithracemicallylhalides AT palacint asymmetriccrosscouplingofalkylalkenylandheteroarylnucleophileswithracemicallylhalides AT fletchers asymmetriccrosscouplingofalkylalkenylandheteroarylnucleophileswithracemicallylhalides |