HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenet...

書目詳細資料
Main Authors:	Ross-Adams, H, Ball, S, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, SH, Ørntoft, TF, Larson, M, Armasu, S, Massie, CE, Asim, M, Mortensen, MM, Borre, M, Woodfine, K, Warren, AY, Lamb, AD, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, KD, Fridley, BL, Goode, EL, Gayther, SA, Masters, J, Neal, DE, Mills, IG
格式:	Journal article
語言:	English
出版:	Rapamycin Press 2016

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