HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenet...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Ross-Adams, H, Ball, S, Lawrenson, K, Halim, S, Russell, R, Wells, C, Strand, SH, Ørntoft, TF, Larson, M, Armasu, S, Massie, CE, Asim, M, Mortensen, MM, Borre, M, Woodfine, K, Warren, AY, Lamb, AD, Kay, J, Whitaker, H, Ramos-Montoya, A, Murrell, A, Sørensen, KD, Fridley, BL, Goode, EL, Gayther, SA, Masters, J, Neal, DE, Mills, IG
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Rapamycin Press 2016

Những quyển sách tương tự

Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.
Bằng: Harries, L, et al.
Được phát hành: (2009)

Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.
Bằng: Lorna W Harries, et al.
Được phát hành: (2009-11-01)

Ovarian cancer: a clinical challenge that needs some basic answers.
Bằng: Kate Lawrenson, et al.
Được phát hành: (2009-02-01)

Structural insights into the HNF4 biology
Bằng: Brice Beinsteiner, et al.
Được phát hành: (2023-06-01)

Management of pregnancy in women with monogenic diabetes due to mutations in GCK, HNF1A and HNF4A genes
Bằng: M. T. Crowley, et al.
Được phát hành: (2024-06-01)

Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes.
Bằng: McDonald, T, et al.
Được phát hành: (2012)

NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α
Bằng: Kezhi Dai, et al.
Được phát hành: (2012-05-01)

Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue
Bằng: Woodfine Kathryn, et al.
Được phát hành: (2011-01-01)

Variants of the HNF4A and HNF1A genes in patients with impaired glucose metabolism and dyslipidemia
Bằng: Dinara E. Ivanoshchuk, et al.
Được phát hành: (2022-01-01)

Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha.
Bằng: Sylvia F Boj, et al.
Được phát hành: (2010-05-01)

The case of HNF-1ß mutation with medullary cysts
Bằng: A Bensouda Mourri, et al.
Được phát hành: (2014-01-01)

An Atypical HNF4A Mutation Which Does Not Conform to the Classic Presentation of HNF4A-MODY
Bằng: Andrew J. Spiro, et al.
Được phát hành: (2018-01-01)

HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.
Bằng: Jürgen Borlak, et al.
Được phát hành: (2009-01-01)

Role of HNF6 in liver homeostasis and pathophysiology
Bằng: Miaomiao Tian, et al.
Được phát hành: (2025-02-01)

HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes
Bằng: Natasha Hui Jin Ng, et al.
Được phát hành: (2024-06-01)

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation
Bằng: Vedrana Vičić Bočkor, et al.
Được phát hành: (2024-01-01)

The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases
Bằng: Liming Chen, et al.
Được phát hành: (2020-06-01)

LncRNA Hnf4αos exacerbates liver ischemia/reperfusion injury in mice via Hnf4αos/Hnf4α duplex-mediated PGC1α suppression
Bằng: Chaoqun Wang, et al.
Được phát hành: (2022-11-01)

Altered cortisol metabolism in individuals with HNF1A-MODY
Bằng: Juszczak, A, et al.
Được phát hành: (2020)

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist
Bằng: Seung-Hee Lee, et al.
Được phát hành: (2021-06-01)

The protein architecture and allosteric landscape of HNF4α
Bằng: Fraydoon Rastinejad
Được phát hành: (2023-09-01)

Structural properties of the HNF-1A transactivation domain
Bằng: Laura Kind, et al.
Được phát hành: (2023-10-01)

Control of ACAT2 liver expression by HNF1
Bằng: Camilla Pramfalk, et al.
Được phát hành: (2005-09-01)

A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells.
Bằng: Seung-Hee Lee, et al.
Được phát hành: (2022-01-01)

Circulating CD36 is reduced in HNF1A-MODY carriers.
Bằng: Siobhan Bacon, et al.
Được phát hành: (2013-01-01)

Nuclear Receptor HNF4α Binding Sequences are Widespread in Alu Repeats
Bằng: Bolotin Eugene, et al.
Được phát hành: (2011-11-01)

Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestine
Bằng: Kiranmayi Vemuri, et al.
Được phát hành: (2023-08-01)

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
Bằng: Shen, H., et al.
Được phát hành: (2013)

Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection
Được phát hành: (2013-09-01)

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1
Bằng: Chen-Hong Ding, et al.
Được phát hành: (2018-02-01)

Genomic Analysis Using Regularized Regression in High-Grade Serous Ovarian Cancer
Bằng: Yanina Natanzon, et al.
Được phát hành: (2018-01-01)

Chemostratigraphy of Jurassic-cretaceous Italian carbonate platforms
Bằng: Woodfine, R, et al.
Được phát hành: (2002)

No attenuation of CRP response to acute inflammation is seen in HNF1A-MODY
Bằng: Owen, K, et al.
Được phát hành: (2013)

Cystatin C is not a good candidate biomarker for HNF1A-MODY.
Bằng: Nowak, N, et al.
Được phát hành: (2013)

Cystatin C is not a good candidate biomarker for HNF1A-MODY
Bằng: Nowak, N, et al.
Được phát hành: (2013)

Maturity onset diabetes of the young due to HNF1A variants in Croatia
Bằng: Pavić, T, et al.
Được phát hành: (2018)

The role of the HNF4alpha enhancer in type 2 diabetes.
Bằng: Mitchell, S, et al.
Được phát hành: (2002)

Variants influencing age at diagnosis of HNF1A-MODY
Bằng: Agnieszka H. Ludwig-Słomczyńska, et al.
Được phát hành: (2022-09-01)

Novel insights into genetics and clinics of the HNF1A-MODY
Bằng: Valkovicova Terezia, et al.
Được phát hành: (2019-04-01)

Integrated bioinformatic analysis of HNF1A in human cancers
Bằng: Enfan Zhang, et al.
Được phát hành: (2021-03-01)