Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.
Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive t...
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797089166305001472 |
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| author | Mathieson, I Munafò, MR Flint, J |
| author_facet | Mathieson, I Munafò, MR Flint, J |
| author_sort | Mathieson, I |
| collection | OXFORD |
| description | Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia. |
| first_indexed | 2024-03-07T03:00:32Z |
| format | Journal article |
| id | oxford-uuid:b0d0e05f-9f0d-438a-ae8b-b0fefa991e6d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:00:32Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:b0d0e05f-9f0d-438a-ae8b-b0fefa991e6d2022-03-27T03:59:10ZMeta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b0d0e05f-9f0d-438a-ae8b-b0fefa991e6dEnglishSymplectic Elements at Oxford2012Mathieson, IMunafò, MRFlint, JSeveral polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia. |
| spellingShingle | Mathieson, I Munafò, MR Flint, J Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. |
| title | Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. |
| title_full | Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. |
| title_fullStr | Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. |
| title_full_unstemmed | Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. |
| title_short | Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. |
| title_sort | meta analysis indicates that common variants at the disc1 locus are not associated with schizophrenia |
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