The emerging role of fumarate as an oncometabolite.

The emerging role of fumarate as an oncometabolite.

The drive to understand how altered cellular metabolism and cancer are linked has caused a paradigm shift in the focus of cancer research. The discovery of a mutated metabolic enzyme, isocitrate dehydrogenase 1, that leads to accumulation of the oncometabolite 2-hydroxyglutarate, provided significan...

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Chi tiết về thư mục
Những tác giả chính:	Yang, M, Soga, T, Pollard, P, Adam, J
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2012

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