Label free redox capacitive biosensing.
A surface confined redox group contributes to an interfacial charging (quantifiable by redox capacitance) that can be sensitively probed by impedance derived capacitance spectroscopy. In generating mixed molecular films comprising such redox groups, together with specific recognition elements (here...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
2013
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| _version_ | 1826291541120909312 |
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| author | Fernandes, F Góes, MS Davis, J Bueno, P |
| author_facet | Fernandes, F Góes, MS Davis, J Bueno, P |
| author_sort | Fernandes, F |
| collection | OXFORD |
| description | A surface confined redox group contributes to an interfacial charging (quantifiable by redox capacitance) that can be sensitively probed by impedance derived capacitance spectroscopy. In generating mixed molecular films comprising such redox groups, together with specific recognition elements (here antibodies), this charging signal is able to sensitively transduce the recognition and binding of specific analytes. This novel transduction method, exemplified here with C-reactive protein, an important biomarker of cardiac status and general trauma, is equally applicable to any suitably prepared interfacial combination of redox reporter and receptor. The assays are label free, ultrasensitive, highly specific and accompanied by a good linear range. |
| first_indexed | 2024-03-07T03:00:56Z |
| format | Journal article |
| id | oxford-uuid:b0f0261f-3df9-4a7b-86d1-a51b932fa293 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:00:56Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:b0f0261f-3df9-4a7b-86d1-a51b932fa2932022-03-27T04:00:11ZLabel free redox capacitive biosensing.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b0f0261f-3df9-4a7b-86d1-a51b932fa293EnglishSymplectic Elements at Oxford2013Fernandes, FGóes, MSDavis, JBueno, PA surface confined redox group contributes to an interfacial charging (quantifiable by redox capacitance) that can be sensitively probed by impedance derived capacitance spectroscopy. In generating mixed molecular films comprising such redox groups, together with specific recognition elements (here antibodies), this charging signal is able to sensitively transduce the recognition and binding of specific analytes. This novel transduction method, exemplified here with C-reactive protein, an important biomarker of cardiac status and general trauma, is equally applicable to any suitably prepared interfacial combination of redox reporter and receptor. The assays are label free, ultrasensitive, highly specific and accompanied by a good linear range. |
| spellingShingle | Fernandes, F Góes, MS Davis, J Bueno, P Label free redox capacitive biosensing. |
| title | Label free redox capacitive biosensing. |
| title_full | Label free redox capacitive biosensing. |
| title_fullStr | Label free redox capacitive biosensing. |
| title_full_unstemmed | Label free redox capacitive biosensing. |
| title_short | Label free redox capacitive biosensing. |
| title_sort | label free redox capacitive biosensing |
| work_keys_str_mv | AT fernandesf labelfreeredoxcapacitivebiosensing AT goesms labelfreeredoxcapacitivebiosensing AT davisj labelfreeredoxcapacitivebiosensing AT buenop labelfreeredoxcapacitivebiosensing |