Effective suppression of HIV-1 replication by cytotoxic T lymphocytes specific for pol epitopes in conserved mosaic vaccine immunogens

Effective suppression of HIV-1 replication by cytotoxic T lymphocytes specific for pol epitopes in conserved mosaic vaccine immunogens

Cytotoxic T lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and recognize circulating HIV-1 could be key for both HIV-1 cure and prophylaxis. We recently designed conserved mosaic T-cell vaccine immunogens tHIVconsvX composed of 6 Gag and Pol regions. Since the tHIVconsvX vacc...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Zou, C, Murakoshi, H, Kuse, N, Akahoshi, T, Chikata, T, Gatanaga, H, Oka, S, Hanke, T, Takiguchi, M
التنسيق:	Journal article
اللغة:	English
منشور في:	American Society for Microbiology 2019

مواد مشابهة

Control of HIV-1 by CD8+T cells specific for epitopes of conserved mosaic vaccine immunogens
حسب: Murakoshi, H, وآخرون
منشور في: (2018)

CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication
حسب: Murakoshi, H, وآخرون
منشور في: (2018)

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control
حسب: Murakoshi, H, وآخرون
منشور في: (2018)

Identification of immunodominant HIV-1 epitopes presented by 2 HLA-C*12:02, a protective allele, using an immunopeptidomics 3 approach
حسب: Chikata, T, وآخرون
منشور في: (2019)

The impact of HLA-Cw*12:02 on control of HIV-1 infection
حسب: Koyanagi M, وآخرون
منشور في: (2012-09-01)

P16-06. Control of HIV-1 by HIV-1 Pol-specific CD8+ T cells in chronically HIV-1-infected Japanese cohort
حسب: Takiguchi M, وآخرون
منشور في: (2009-10-01)

HIV-1 protective epitope-specific CD8+ T cells in HIV-1-exposed seronegative individuals
حسب: Takayuki Chikata, وآخرون
منشور في: (2023-11-01)

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 controlResearch in Context
حسب: Hayato Murakoshi, وآخرون
منشور في: (2018-10-01)

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.
حسب: Tomohiro Akahoshi, وآخرون
منشور في: (2020-12-01)

Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine
حسب: Nozomi Kuse, وآخرون
منشور في: (2022-09-01)

Cross-clade CTL recognitions for clade B and A/E viruses in A/E virus-infected Japanese individuals
حسب: Watanabe K, وآخرون
منشور في: (2012-09-01)

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
حسب: Frahm, N, وآخرون
منشور في: (2006)

Control of HIV-1 by multiple immunodominant HIV-1-specific CD8+ T cells in HIV-1-infected Japanese individuals
حسب: Murakoshi H, وآخرون
منشور في: (2012-09-01)

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.
حسب: Borthwick, N, وآخرون
منشور في: (2017)

Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101.
حسب: Kawashima, Y, وآخرون
منشور في: (2010)

Identification of novel HIV-1-derived HLA-E-binding peptides
حسب: Hannoun, Z, وآخرون
منشور في: (2018)

Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals.
حسب: Juan Blanco-Heredia, وآخرون
منشور في: (2016-01-01)

Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes.
حسب: Gileadi, U, وآخرون
منشور في: (1999)

CYTOTOXIC T-LYMPHOCYTE RECOGNITION OF HIV - EPITOPE SELECTION AND ESCAPE
حسب: Mcmichael, A, وآخرون
منشور في: (1993)

Correction: Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals.
حسب: Juan Blanco-Heredia, وآخرون
منشور في: (2016-01-01)

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.
حسب: Nicola Borthwick, وآخرون
منشور في: (2017-01-01)

Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction
حسب: Lund Ole, وآخرون
منشور في: (2007-10-01)

Identification of cytotoxic T lymphocyte epitopes on swine viruses: multi-epitope design for universal T cell vaccine.
حسب: Yu-Chieh Liao, وآخرون
منشور في: (2013-01-01)

Conservation within cytotoxic T lymphocyte epitopes in hepatitis C virus in chronic infection.
حسب: Christie, J, وآخرون
منشور في: (1997)

Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes
حسب: Peng Peng Ip, وآخرون
منشور في: (2015-03-01)

Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins
حسب: Wu Shipo, وآخرون
منشور في: (2012-06-01)

P16-22. In impact of nadir CD4 counts on skewed distributions of functional subsets in peripheral CD4+ T cells in patients chronically infected with HIV-1
حسب: Takiguchi M, وآخرون
منشور في: (2009-10-01)

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.
حسب: Matthews, P, وآخرون
منشور في: (2012)

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice.
حسب: Hanke, T, وآخرون
منشور في: (1998)

Comparative Immunogenicity of a Cytotoxic T Cell Epitope Delivered by Penetratin and TAT Cell Penetrating Peptides
حسب: Nicole Brooks, وآخرون
منشور في: (2015-08-01)

Cytotoxic T lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission in Tanzania.
حسب: Lalvani, A, وآخرون
منشور في: (1996)

Cytotoxic T lymphocyte epitopes in hepatitis C virus identified with HLA assembly assays.
حسب: Healey, C, وآخرون
منشور في: (1996)

Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12.
حسب: Eberl, G, وآخرون
منشور في: (1996)

Impact of micropolymorphism outside the 1 peptide binding groove in the clinically-relevant allele HLA-C*14 on T cell responses in HIV-1 infection
حسب: Chikata, T, وآخرون
منشور في: (2022)

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
حسب: Sewell, A, وآخرون
منشور في: (1999)

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.
حسب: Townsend, A, وآخرون
منشور في: (1986)

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.
حسب: Klenerman, P, وآخرون
منشور في: (1998)

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
حسب: Townsend, A, وآخرون
منشور في: (1986)

Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
حسب: Goulder, P, وآخرون
منشور في: (2000)

Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage.
حسب: Paul W Fenimore, وآخرون
منشور في: (2012-01-01)