Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells
MT1-MMP plays a crucial role in promoting the cellular invasion of cancer cells by degrading the extracellular matrix to create a path for migration. During this process, its localization at the leading edge of migrating cells is critical, and it is achieved by targeted transport of MT1-MMP-containi...
Main Authors: | Gifford, V, Woskowicz, A, Ito, N, Balint, S, Lagerholm, B, Dustin, M, Itoh, Y |
---|---|
פורמט: | Journal article |
שפה: | English |
יצא לאור: |
Elsevier
2022
|
פריטים דומים
-
The kinesin superfamily protein KIF17: one protein with many functions
מאת: Wong-Riley Margaret T.T., et al.
יצא לאור: (2012-06-01) -
Cell surface localization of MT1-MMP to the matrix attachment site: Effect of CD44 and MT-Loop region of MT1-MMP
מאת: Woskowicz, A, et al.
יצא לאור: (2010) -
MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion.
מאת: Woskowicz, A, et al.
יצא לאור: (2013) -
MT1-MMP: a potent modifier of pericellular microenvironment.
מאת: Itoh, Y, et al.
יצא לאור: (2006) -
Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)
מאת: Cuffaro, D, et al.
יצא לאור: (2018)