Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells
MT1-MMP plays a crucial role in promoting the cellular invasion of cancer cells by degrading the extracellular matrix to create a path for migration. During this process, its localization at the leading edge of migrating cells is critical, and it is achieved by targeted transport of MT1-MMP-containi...
Автори: | Gifford, V, Woskowicz, A, Ito, N, Balint, S, Lagerholm, B, Dustin, M, Itoh, Y |
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Формат: | Journal article |
Мова: | English |
Опубліковано: |
Elsevier
2022
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