Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this stu...
| मुख्य लेखकों: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2009
|
| _version_ | 1826291550021222400 |
|---|---|
| author | Stern, M Lin, J Figueroa, J Kelsey, K Kiltie, A Yuan, J Matullo, G Fletcher, T Benhamou, S Taylor, J Placidi, D Zhang, Z Steineck, G Rothman, N Kogevinas, M Silverman, D Malats, N Chanock, S Wu, X Karagas, MR Andrew, A Nelson, H Bishop, D Sak, S Choudhury, A |
| author_facet | Stern, M Lin, J Figueroa, J Kelsey, K Kiltie, A Yuan, J Matullo, G Fletcher, T Benhamou, S Taylor, J Placidi, D Zhang, Z Steineck, G Rothman, N Kogevinas, M Silverman, D Malats, N Chanock, S Wu, X Karagas, MR Andrew, A Nelson, H Bishop, D Sak, S Choudhury, A |
| author_sort | Stern, M |
| collection | OXFORD |
| description | Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis. |
| first_indexed | 2024-03-07T03:01:04Z |
| format | Journal article |
| id | oxford-uuid:b0fa3dd7-78a5-4f7e-b137-d0ce1574eb8a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:01:04Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:b0fa3dd7-78a5-4f7e-b137-d0ce1574eb8a2022-03-27T04:00:31ZPolymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b0fa3dd7-78a5-4f7e-b137-d0ce1574eb8aEnglishSymplectic Elements at Oxford2009Stern, MLin, JFigueroa, JKelsey, KKiltie, AYuan, JMatullo, GFletcher, TBenhamou, STaylor, JPlacidi, DZhang, ZSteineck, GRothman, NKogevinas, MSilverman, DMalats, NChanock, SWu, XKaragas, MRAndrew, ANelson, HBishop, DSak, SChoudhury, ATobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis. |
| spellingShingle | Stern, M Lin, J Figueroa, J Kelsey, K Kiltie, A Yuan, J Matullo, G Fletcher, T Benhamou, S Taylor, J Placidi, D Zhang, Z Steineck, G Rothman, N Kogevinas, M Silverman, D Malats, N Chanock, S Wu, X Karagas, MR Andrew, A Nelson, H Bishop, D Sak, S Choudhury, A Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. |
| title | Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. |
| title_full | Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. |
| title_fullStr | Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. |
| title_full_unstemmed | Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. |
| title_short | Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. |
| title_sort | polymorphisms in dna repair genes smoking and bladder cancer risk findings from the international consortium of bladder cancer |
| work_keys_str_mv | AT sternm polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT linj polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT figueroaj polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT kelseyk polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT kiltiea polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT yuanj polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT matullog polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT fletchert polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT benhamous polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT taylorj polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT placidid polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT zhangz polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT steineckg polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT rothmann polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT kogevinasm polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT silvermand polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT malatsn polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT chanocks polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT wux polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT karagasmr polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT andrewa polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT nelsonh polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT bishopd polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT saks polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer AT choudhurya polymorphismsindnarepairgenessmokingandbladdercancerriskfindingsfromtheinternationalconsortiumofbladdercancer |