Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis

Endometriosis is a condition where endometrial-like tissues grow outside the uterus, leading to inflammation, pain, and reduced fertility. Treatment is generally hormonal or surgical, and noninvasive, nonhormonal therapies are urgently needed. Here, Tapmeier and colleagues performed genetic analyses...

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Main Authors: Tapmeier, TT, Rahmioglu, N, Lin, J, De Leo, B, Obendorf, M, Raveendran, M, Fischer, OM, Bafligil, C, Guo, M, Harris, RA, Hess-Stumpp, H, Laux-Biehlmann, A, Lowy, E, Lunter, G, Malzahn, J, Martin, NG, Martinez-Estrada, F, Manek, S, Mesch, S, Montgomery, GW, Morris, AP, Nagel, J, Simmons, HA, Brocklebank, D, Shang, C, Treloar, S, Wells, G, Becker, C, Oppermann, U, Zollner, TM, Kennedy, SH, Kemnitz, J, Rogers, J, Zondervan, KT
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2021
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author Tapmeier, TT
Rahmioglu, N
Lin, J
De Leo, B
Obendorf, M
Raveendran, M
Fischer, OM
Bafligil, C
Guo, M
Harris, RA
Hess-Stumpp, H
Laux-Biehlmann, A
Lowy, E
Lunter, G
Malzahn, J
Martin, NG
Martinez-Estrada, F
Manek, S
Mesch, S
Montgomery, GW
Morris, AP
Nagel, J
Simmons, HA
Brocklebank, D
Shang, C
Treloar, S
Wells, G
Becker, C
Oppermann, U
Zollner, TM
Kennedy, SH
Kemnitz, J
Rogers, J
Zondervan, KT
author_facet Tapmeier, TT
Rahmioglu, N
Lin, J
De Leo, B
Obendorf, M
Raveendran, M
Fischer, OM
Bafligil, C
Guo, M
Harris, RA
Hess-Stumpp, H
Laux-Biehlmann, A
Lowy, E
Lunter, G
Malzahn, J
Martin, NG
Martinez-Estrada, F
Manek, S
Mesch, S
Montgomery, GW
Morris, AP
Nagel, J
Simmons, HA
Brocklebank, D
Shang, C
Treloar, S
Wells, G
Becker, C
Oppermann, U
Zollner, TM
Kennedy, SH
Kemnitz, J
Rogers, J
Zondervan, KT
author_sort Tapmeier, TT
collection OXFORD
description Endometriosis is a condition where endometrial-like tissues grow outside the uterus, leading to inflammation, pain, and reduced fertility. Treatment is generally hormonal or surgical, and noninvasive, nonhormonal therapies are urgently needed. Here, Tapmeier and colleagues performed genetic analyses of human families with endometriosis and rhesus macaques that spontaneously develop endometriosis, identifying NPSR1, the gene encoding neuropeptide S receptor 1, as associated with disease. The NPSR1 inhibitor SHA 68R led to reduction of inflammatory cell infiltrate and pain in mouse models of peritoneal inflammation and endometriosis. Although further studies in nonhuman primates are needed, the findings give hope for a nonhormonal treatment for endometriosis.
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spelling oxford-uuid:b1148164-6faf-4dc4-a72b-450a817dab042022-03-27T04:01:23ZNeuropeptide S receptor 1 is a nonhormonal treatment target in endometriosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b1148164-6faf-4dc4-a72b-450a817dab04EnglishSymplectic ElementsAmerican Association for the Advancement of Science2021Tapmeier, TTRahmioglu, NLin, JDe Leo, BObendorf, MRaveendran, MFischer, OMBafligil, CGuo, MHarris, RAHess-Stumpp, HLaux-Biehlmann, ALowy, ELunter, GMalzahn, JMartin, NGMartinez-Estrada, FManek, SMesch, SMontgomery, GWMorris, APNagel, JSimmons, HABrocklebank, DShang, CTreloar, SWells, GBecker, COppermann, UZollner, TMKennedy, SHKemnitz, JRogers, JZondervan, KTEndometriosis is a condition where endometrial-like tissues grow outside the uterus, leading to inflammation, pain, and reduced fertility. Treatment is generally hormonal or surgical, and noninvasive, nonhormonal therapies are urgently needed. Here, Tapmeier and colleagues performed genetic analyses of human families with endometriosis and rhesus macaques that spontaneously develop endometriosis, identifying NPSR1, the gene encoding neuropeptide S receptor 1, as associated with disease. The NPSR1 inhibitor SHA 68R led to reduction of inflammatory cell infiltrate and pain in mouse models of peritoneal inflammation and endometriosis. Although further studies in nonhuman primates are needed, the findings give hope for a nonhormonal treatment for endometriosis.
spellingShingle Tapmeier, TT
Rahmioglu, N
Lin, J
De Leo, B
Obendorf, M
Raveendran, M
Fischer, OM
Bafligil, C
Guo, M
Harris, RA
Hess-Stumpp, H
Laux-Biehlmann, A
Lowy, E
Lunter, G
Malzahn, J
Martin, NG
Martinez-Estrada, F
Manek, S
Mesch, S
Montgomery, GW
Morris, AP
Nagel, J
Simmons, HA
Brocklebank, D
Shang, C
Treloar, S
Wells, G
Becker, C
Oppermann, U
Zollner, TM
Kennedy, SH
Kemnitz, J
Rogers, J
Zondervan, KT
Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
title Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
title_full Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
title_fullStr Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
title_full_unstemmed Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
title_short Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis
title_sort neuropeptide s receptor 1 is a nonhormonal treatment target in endometriosis
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