Preventing postoperative recurrence of Crohn's disease.
BACKGROUND AND METHODS: Risk factors for recurrence of Crohn's disease and the evidence for progress in reducing recurrence following resection were reviewed. A Medline based literature review was carried out. RESULTS AND CONCLUSION: Only smoking has been confirmed as a significant adverse ris...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1997
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| _version_ | 1797089258786258944 |
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| author | Borley, N Mortensen, N Jewell, D |
| author_facet | Borley, N Mortensen, N Jewell, D |
| author_sort | Borley, N |
| collection | OXFORD |
| description | BACKGROUND AND METHODS: Risk factors for recurrence of Crohn's disease and the evidence for progress in reducing recurrence following resection were reviewed. A Medline based literature review was carried out. RESULTS AND CONCLUSION: Only smoking has been confirmed as a significant adverse risk factor for recurrence. Evidence for differing recurrence rates in fibrostenosing disease and perforating disease is inconclusive, but such a classification along with the endoscopic findings of recurrence may have a place in the analysis of therapeutic trials. Minimal resectional surgery with clearing of only macroscopic disease seems to be justified, with no clear benefits from different anastomotic techniques. Recent trials offer encouraging evidence of the usefulness of 5-aminosalicylic acid, particularly higher-dose regimens started early after resection, although the long-term benefits are uncertain. The oral steroid, budesonide, offers a potent treatment with minimal side-effects, but evidence of its prevention of recurrence is presently weak. |
| first_indexed | 2024-03-07T03:01:47Z |
| format | Journal article |
| id | oxford-uuid:b12fec1d-7cb1-4523-9c35-47a8db2b839c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:01:47Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:b12fec1d-7cb1-4523-9c35-47a8db2b839c2022-03-27T04:02:13ZPreventing postoperative recurrence of Crohn's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b12fec1d-7cb1-4523-9c35-47a8db2b839cEnglishSymplectic Elements at Oxford1997Borley, NMortensen, NJewell, D BACKGROUND AND METHODS: Risk factors for recurrence of Crohn's disease and the evidence for progress in reducing recurrence following resection were reviewed. A Medline based literature review was carried out. RESULTS AND CONCLUSION: Only smoking has been confirmed as a significant adverse risk factor for recurrence. Evidence for differing recurrence rates in fibrostenosing disease and perforating disease is inconclusive, but such a classification along with the endoscopic findings of recurrence may have a place in the analysis of therapeutic trials. Minimal resectional surgery with clearing of only macroscopic disease seems to be justified, with no clear benefits from different anastomotic techniques. Recent trials offer encouraging evidence of the usefulness of 5-aminosalicylic acid, particularly higher-dose regimens started early after resection, although the long-term benefits are uncertain. The oral steroid, budesonide, offers a potent treatment with minimal side-effects, but evidence of its prevention of recurrence is presently weak. |
| spellingShingle | Borley, N Mortensen, N Jewell, D Preventing postoperative recurrence of Crohn's disease. |
| title | Preventing postoperative recurrence of Crohn's disease. |
| title_full | Preventing postoperative recurrence of Crohn's disease. |
| title_fullStr | Preventing postoperative recurrence of Crohn's disease. |
| title_full_unstemmed | Preventing postoperative recurrence of Crohn's disease. |
| title_short | Preventing postoperative recurrence of Crohn's disease. |
| title_sort | preventing postoperative recurrence of crohn s disease |
| work_keys_str_mv | AT borleyn preventingpostoperativerecurrenceofcrohnsdisease AT mortensenn preventingpostoperativerecurrenceofcrohnsdisease AT jewelld preventingpostoperativerecurrenceofcrohnsdisease |