Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression.
We investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, on 5-HT1A and 5-HT2A receptor mRNA and binding site densities in the rat brain using in situ hybridization histochemistry and quantitative autoradiography. ECS treatment increased 5-HT1A receptor mRNA...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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| _version_ | 1797089268512849920 |
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| author | Burnet, P Mead, A Eastwood, S Lacey, K Harrison, P Sharp, T |
| author_facet | Burnet, P Mead, A Eastwood, S Lacey, K Harrison, P Sharp, T |
| author_sort | Burnet, P |
| collection | OXFORD |
| description | We investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, on 5-HT1A and 5-HT2A receptor mRNA and binding site densities in the rat brain using in situ hybridization histochemistry and quantitative autoradiography. ECS treatment increased 5-HT1A receptor mRNA abundance and binding site densities in the dentate gyrus, but decreased these parameters in the CA3c layer of the hippocampus. No changes in 5-HT1A receptor mRNA and binding sites occurred in other hippocampal subfields, neocortex or raphe nuclei. Repeated ECS was also found to increase 5-HT2A receptor binding site densities in the neocortex and this was accompanied by a non-significant increase in cortical 5-HT2A receptor mRNA abundance. Our study demonstrates that in the rat, repeated ECS produces anatomically and molecularly discrete effects on 5-HT1A and 5-HT2A receptor gene expression. These changes may be relevant to the therapeutic effect of repeated ECS in depression. |
| first_indexed | 2024-03-07T03:01:56Z |
| format | Journal article |
| id | oxford-uuid:b13ffa47-d0bc-4e2c-b866-7a6411556954 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:01:56Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:b13ffa47-d0bc-4e2c-b866-7a64115569542022-03-27T04:02:34ZRepeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b13ffa47-d0bc-4e2c-b866-7a6411556954EnglishSymplectic Elements at Oxford1995Burnet, PMead, AEastwood, SLacey, KHarrison, PSharp, TWe investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, on 5-HT1A and 5-HT2A receptor mRNA and binding site densities in the rat brain using in situ hybridization histochemistry and quantitative autoradiography. ECS treatment increased 5-HT1A receptor mRNA abundance and binding site densities in the dentate gyrus, but decreased these parameters in the CA3c layer of the hippocampus. No changes in 5-HT1A receptor mRNA and binding sites occurred in other hippocampal subfields, neocortex or raphe nuclei. Repeated ECS was also found to increase 5-HT2A receptor binding site densities in the neocortex and this was accompanied by a non-significant increase in cortical 5-HT2A receptor mRNA abundance. Our study demonstrates that in the rat, repeated ECS produces anatomically and molecularly discrete effects on 5-HT1A and 5-HT2A receptor gene expression. These changes may be relevant to the therapeutic effect of repeated ECS in depression. |
| spellingShingle | Burnet, P Mead, A Eastwood, S Lacey, K Harrison, P Sharp, T Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. |
| title | Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. |
| title_full | Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. |
| title_fullStr | Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. |
| title_full_unstemmed | Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. |
| title_short | Repeated ECS differentially affects rat brain 5-HT1A and 5-HT2A receptor expression. |
| title_sort | repeated ecs differentially affects rat brain 5 ht1a and 5 ht2a receptor expression |
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