The quality of function of renal allografts is associated with donor age.

The quality of renal allograft function was assessed by prospective measurement of creatinine clearance at 1 year (n = 197) and at 3 years (n = 115) after cadaveric renal transplantation in a cohort of 268 patients treated with triple therapy immunosuppression. Donor age (P < 0.0012) and reci...

Full description

Bibliographic Details
Main Authors: Higgins, R, Sheriff, R, Bittar, A, Richardson, A, Ratcliffe, P, Gray, D, Morris, P
Format: Journal article
Language:English
Published: Springer-Verlag 1995
_version_ 1797089318249955328
author Higgins, R
Sheriff, R
Bittar, A
Richardson, A
Ratcliffe, P
Gray, D
Morris, P
author_facet Higgins, R
Sheriff, R
Bittar, A
Richardson, A
Ratcliffe, P
Gray, D
Morris, P
author_sort Higgins, R
collection OXFORD
description The quality of renal allograft function was assessed by prospective measurement of creatinine clearance at 1 year (n = 197) and at 3 years (n = 115) after cadaveric renal transplantation in a cohort of 268 patients treated with triple therapy immunosuppression. Donor age (P < 0.0012) and recipient age (P < 0.01) were independently associated with creatinine clearance both at 1 and at 3 years. In patients with donor age above 50 years and recipient age above 45 years, the mean creatinine clearance was 32.7 (SD 10.4) ml/min (n = 27). When the donor age was below 30 years and recipient age below 45 years, the mean creatinine clearance was 55.6 (SD 14.4) ml/min (n = 47, P < 0.001). However, in these patients there was no significant association between graft function and many of the factors known to influence graft survival, such as HLA matching, sensitisation of the recipient, and the occurrence of rejection. In conclusion, the quality of renal allograft function declined with increasing donor and recipient age in our patients, whilst immunological factors were not significantly associated with function in surviving grafts.
first_indexed 2024-03-07T03:02:27Z
format Journal article
id oxford-uuid:b1688249-6305-4c03-9c5c-7c53a0ec35fd
institution University of Oxford
language English
last_indexed 2024-03-07T03:02:27Z
publishDate 1995
publisher Springer-Verlag
record_format dspace
spelling oxford-uuid:b1688249-6305-4c03-9c5c-7c53a0ec35fd2022-03-27T04:03:51ZThe quality of function of renal allografts is associated with donor age.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b1688249-6305-4c03-9c5c-7c53a0ec35fdEnglishSymplectic Elements at OxfordSpringer-Verlag1995Higgins, RSheriff, RBittar, ARichardson, ARatcliffe, PGray, DMorris, PThe quality of renal allograft function was assessed by prospective measurement of creatinine clearance at 1 year (n = 197) and at 3 years (n = 115) after cadaveric renal transplantation in a cohort of 268 patients treated with triple therapy immunosuppression. Donor age (P < 0.0012) and recipient age (P < 0.01) were independently associated with creatinine clearance both at 1 and at 3 years. In patients with donor age above 50 years and recipient age above 45 years, the mean creatinine clearance was 32.7 (SD 10.4) ml/min (n = 27). When the donor age was below 30 years and recipient age below 45 years, the mean creatinine clearance was 55.6 (SD 14.4) ml/min (n = 47, P < 0.001). However, in these patients there was no significant association between graft function and many of the factors known to influence graft survival, such as HLA matching, sensitisation of the recipient, and the occurrence of rejection. In conclusion, the quality of renal allograft function declined with increasing donor and recipient age in our patients, whilst immunological factors were not significantly associated with function in surviving grafts.
spellingShingle Higgins, R
Sheriff, R
Bittar, A
Richardson, A
Ratcliffe, P
Gray, D
Morris, P
The quality of function of renal allografts is associated with donor age.
title The quality of function of renal allografts is associated with donor age.
title_full The quality of function of renal allografts is associated with donor age.
title_fullStr The quality of function of renal allografts is associated with donor age.
title_full_unstemmed The quality of function of renal allografts is associated with donor age.
title_short The quality of function of renal allografts is associated with donor age.
title_sort quality of function of renal allografts is associated with donor age
work_keys_str_mv AT higginsr thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT sheriffr thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT bittara thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT richardsona thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT ratcliffep thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT grayd thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT morrisp thequalityoffunctionofrenalallograftsisassociatedwithdonorage
AT higginsr qualityoffunctionofrenalallograftsisassociatedwithdonorage
AT sheriffr qualityoffunctionofrenalallograftsisassociatedwithdonorage
AT bittara qualityoffunctionofrenalallograftsisassociatedwithdonorage
AT richardsona qualityoffunctionofrenalallograftsisassociatedwithdonorage
AT ratcliffep qualityoffunctionofrenalallograftsisassociatedwithdonorage
AT grayd qualityoffunctionofrenalallograftsisassociatedwithdonorage
AT morrisp qualityoffunctionofrenalallograftsisassociatedwithdonorage