Facilitation by intracellular carbonic anhydrase of Na+-HCO3 - co-transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte

Facilitation by intracellular carbonic anhydrase of Na+-HCO3 - co-transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte

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Carbonic anhydrase enzymes (CAs) catalyse the reversible hydration of CO2 to H+ and HCO3- ions. This catalysis is proposed to be harnessed by acid/base transporters, to facilitate their transmembrane flux activity, either through direct protein-protein binding (a 'transport metabolon') or...

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Bibliographic Details
Main Authors: Villafuerte, F, Swietach, P, Youm, J, Ford, K, Cardenas, R, Supuran, C, Cobden, P, Rohling, M, Vaughan-Jones, R
Format: Journal article
Language:English
Published: 2014

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