Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl hydroxylases plays a pivotal role in regulating HIF stability. The biochemical properties of these enzymes make them well suited to act as oxygen sensors. They also r...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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