Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort
<strong>Background:<br></strong> Retinal nerve fiber layer (RNFL) thickness may reflect cerebral status. <br><strong> Objective:<br></strong> This study assessed the relationship between RNFL thickness and incident all-cause dementia in the European Prospect...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
IOS Press
2023
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| _version_ | 1797111516556689408 |
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| author | Yin, GS van der Heide, F Littlejohns, TJ Kuźma, E Hayat, S Brayne, C Foster, PJ Luben, R Khawaja, AP |
| author_facet | Yin, GS van der Heide, F Littlejohns, TJ Kuźma, E Hayat, S Brayne, C Foster, PJ Luben, R Khawaja, AP |
| author_sort | Yin, GS |
| collection | OXFORD |
| description | <strong>Background:<br></strong>
Retinal nerve fiber layer (RNFL) thickness may reflect cerebral status.
<br><strong>
Objective:<br></strong>
This study assessed the relationship between RNFL thickness and incident all-cause dementia in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) Eye Study.
<br><strong>
Methods:<br></strong>
Glaucoma detection with variable corneal compensation (GDx-VCC) and Heidelberg Retinal Tomograph II (HRT II) derived global mean RNFL thickness from dementia-free participants at baseline within the EPIC-Norfolk Eye Study were analyzed. Incident dementia was identified through linkage to electronic medical records. Cox proportional hazard mixed-effects regression models adjusted for key confounders were used to examine the associations between RNFL thickness and incident dementia in four separate models.
<br><strong>
Results:<br></strong>
6,239 participants were included with 322 cases of incident dementia and mean age of 67.5-years old, with 49.7% women (median follow-up 13.2-years, interquartile range (11.7 to 14.6 years). Greater RNFL thickness (GDx-VCC) was not significantly associated with a lower risk of incident dementia in the full adjusted model [HR per quartile increase 0.95; 95% CI 0.82–1.10]. Similarly, RNFL thickness assessed with HRT II was also not associated with incident dementia in any model (full adjusted model; HR per quartile increase: 1.06; [95% CI 0.93–1.19]. Gender did not modify any associations under study.
<br><strong>
Conclusion:<br></strong>
GDx-VCC and HRT II derived RNFL thickness are unlikely to be useful predictors of incident dementia. Higher resolution optical imaging technologies may clarify whether there are useful relationships between neuro-retinal morphology and brain measures. |
| first_indexed | 2024-03-07T08:09:59Z |
| format | Journal article |
| id | oxford-uuid:b19bc712-eb6d-45db-becd-4dd89851bccb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:09:59Z |
| publishDate | 2023 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | oxford-uuid:b19bc712-eb6d-45db-becd-4dd89851bccb2023-11-22T12:20:29ZAssociation between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b19bc712-eb6d-45db-becd-4dd89851bccbEnglishSymplectic ElementsIOS Press2023Yin, GSvan der Heide, FLittlejohns, TJKuźma, EHayat, SBrayne, CFoster, PJLuben, RKhawaja, AP<strong>Background:<br></strong> Retinal nerve fiber layer (RNFL) thickness may reflect cerebral status. <br><strong> Objective:<br></strong> This study assessed the relationship between RNFL thickness and incident all-cause dementia in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) Eye Study. <br><strong> Methods:<br></strong> Glaucoma detection with variable corneal compensation (GDx-VCC) and Heidelberg Retinal Tomograph II (HRT II) derived global mean RNFL thickness from dementia-free participants at baseline within the EPIC-Norfolk Eye Study were analyzed. Incident dementia was identified through linkage to electronic medical records. Cox proportional hazard mixed-effects regression models adjusted for key confounders were used to examine the associations between RNFL thickness and incident dementia in four separate models. <br><strong> Results:<br></strong> 6,239 participants were included with 322 cases of incident dementia and mean age of 67.5-years old, with 49.7% women (median follow-up 13.2-years, interquartile range (11.7 to 14.6 years). Greater RNFL thickness (GDx-VCC) was not significantly associated with a lower risk of incident dementia in the full adjusted model [HR per quartile increase 0.95; 95% CI 0.82–1.10]. Similarly, RNFL thickness assessed with HRT II was also not associated with incident dementia in any model (full adjusted model; HR per quartile increase: 1.06; [95% CI 0.93–1.19]. Gender did not modify any associations under study. <br><strong> Conclusion:<br></strong> GDx-VCC and HRT II derived RNFL thickness are unlikely to be useful predictors of incident dementia. Higher resolution optical imaging technologies may clarify whether there are useful relationships between neuro-retinal morphology and brain measures. |
| spellingShingle | Yin, GS van der Heide, F Littlejohns, TJ Kuźma, E Hayat, S Brayne, C Foster, PJ Luben, R Khawaja, AP Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort |
| title | Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort |
| title_full | Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort |
| title_fullStr | Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort |
| title_full_unstemmed | Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort |
| title_short | Association between retinal nerve fiber layer thickness and incident dementia in the European Prospective Investigation into Cancer in Norfolk cohort |
| title_sort | association between retinal nerve fiber layer thickness and incident dementia in the european prospective investigation into cancer in norfolk cohort |
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