Autoantibodies in neuromuscular transmission disorders.
It is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field of autoantibodies in myasthenia gravis and other neurotransmission disorders. The neuromuscular junction (NMJ) is the site of a number of different autoimmune and genetic disorders, and it is also the...
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797089397712093184 |
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| author | Vincent, A |
| author_facet | Vincent, A |
| author_sort | Vincent, A |
| collection | OXFORD |
| description | It is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field of autoantibodies in myasthenia gravis and other neurotransmission disorders. The neuromuscular junction (NMJ) is the site of a number of different autoimmune and genetic disorders, and it is also the target of many neurotoxins from venomous snakes, spiders, scorpions and other species. The molecular organization of the NMJ is graphically represented in Figure 1A, where different ion channels, receptors and other proteins are shown. Four of the ion channels or receptors are directly involved in autoimmune diseases. This brief review will not only concentrate on these conditions but also illustrate how their study is helping us to understand the etiology of rare but treatable neurological syndromes of the central nervous system. |
| first_indexed | 2024-03-07T03:03:35Z |
| format | Journal article |
| id | oxford-uuid:b1c388c2-a4c9-4391-b421-f39ca6830696 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:03:35Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:b1c388c2-a4c9-4391-b421-f39ca68306962022-03-27T04:06:33ZAutoantibodies in neuromuscular transmission disorders.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b1c388c2-a4c9-4391-b421-f39ca6830696EnglishSymplectic Elements at Oxford2008Vincent, AIt is a great pleasure to be asked to honour the memory of Dr. Baldev Singh by reviewing the field of autoantibodies in myasthenia gravis and other neurotransmission disorders. The neuromuscular junction (NMJ) is the site of a number of different autoimmune and genetic disorders, and it is also the target of many neurotoxins from venomous snakes, spiders, scorpions and other species. The molecular organization of the NMJ is graphically represented in Figure 1A, where different ion channels, receptors and other proteins are shown. Four of the ion channels or receptors are directly involved in autoimmune diseases. This brief review will not only concentrate on these conditions but also illustrate how their study is helping us to understand the etiology of rare but treatable neurological syndromes of the central nervous system. |
| spellingShingle | Vincent, A Autoantibodies in neuromuscular transmission disorders. |
| title | Autoantibodies in neuromuscular transmission disorders. |
| title_full | Autoantibodies in neuromuscular transmission disorders. |
| title_fullStr | Autoantibodies in neuromuscular transmission disorders. |
| title_full_unstemmed | Autoantibodies in neuromuscular transmission disorders. |
| title_short | Autoantibodies in neuromuscular transmission disorders. |
| title_sort | autoantibodies in neuromuscular transmission disorders |
| work_keys_str_mv | AT vincenta autoantibodiesinneuromusculartransmissiondisorders |