Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Hydroxylation of two conserved prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of the alpha-subunit of hypoxia-inducible factor (HIF) signals for its degradation via the ubiquitin-proteasome pathway. In human cells, three prolyl hydroxylases (PHDs 1-3) b...

Podrobná bibliografie
Hlavní autoři:	Flashman, E, Bagg, E, Chowdhury, R, Mecinović, J, Loenarz, C, McDonough, M, Hewitson, K, Schofield, C
Médium:	Journal article
Jazyk:	English
Vydáno:	2008

Podobné jednotky

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Autor: Chowdhury, R, a další
Vydáno: (2009)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
Autor: Mecinović, J, a další
Vydáno: (2009)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
Autor: Chowdhury, R, a další
Vydáno: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
Autor: Chowdhury, R, a další
Vydáno: (2011)

Substrate selectivity of prolyl hydroxylases
Autor: McDonough, M
Vydáno: (2018)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
Autor: Mecinovic, J, a další
Vydáno: (2008)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
Autor: Abboud, M, a další
Vydáno: (2018)

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
Autor: Mecinović, J, a další
Vydáno: (2009)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
Autor: Lippl, K, a další
Vydáno: (2015)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Autor: McDonough, M, a další
Vydáno: (2006)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
Autor: Hewitson, K, a další
Vydáno: (2007)

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
Autor: Bush, J, a další
Vydáno: (2018)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
Autor: Mecinovic, J, a další
Vydáno: (2007)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
Autor: Flashman, E, a další
Vydáno: (2010)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
Autor: Flashman, E, a další
Vydáno: (2010)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
Autor: Flashman, E, a další
Vydáno: (2010)

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
Autor: Lippl, K, a další
Vydáno: (2018)

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.
Autor: Mecinović, J, a další
Vydáno: (2008)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
Autor: McNeill, L, a další
Vydáno: (2005)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
Autor: Horita, S, a další
Vydáno: (2015)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
Autor: Liu, T, a další
Vydáno: (2020)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
Autor: Figg, WD, a další
Vydáno: (2023)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
Autor: Figg, WD, a další
Vydáno: (2021)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Autor: Chowdhury, R, a další
Vydáno: (2013)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
Autor: Conejo-Garcia, A, a další
Vydáno: (2005)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
Autor: Tarhonskaya, H, a další
Vydáno: (2014)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
Autor: Abboud, M, a další
Vydáno: (2018)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
Autor: Holt-Martyn, J, a další
Vydáno: (2019)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Autor: Mole, D, a další
Vydáno: (2003)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
Autor: Chan, M, a další
Vydáno: (2016)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
Autor: Lancaster, D, a další
Vydáno: (2004)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
Autor: McNeill, L, a další
Vydáno: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Autor: Schlemminger, I, a další
Vydáno: (2003)

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
Autor: Ehrismann, D, a další
Vydáno: (2007)

Inhibition of a viral prolyl hydroxylase
Autor: Langley, G, a další
Vydáno: (2019)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
Autor: Domene, C, a další
Vydáno: (2020)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
Autor: Li, Z, a další
Vydáno: (2020)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
Autor: Kiriakidis, S, a další
Vydáno: (2017)

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
Autor: Stubbs, C, a další
Vydáno: (2009)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
Autor: Astuti, D, a další
Vydáno: (2010)