Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Hydroxylation of two conserved prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of the alpha-subunit of hypoxia-inducible factor (HIF) signals for its degradation via the ubiquitin-proteasome pathway. In human cells, three prolyl hydroxylases (PHDs 1-3) b...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Flashman, E, Bagg, E, Chowdhury, R, Mecinović, J, Loenarz, C, McDonough, M, Hewitson, K, Schofield, C
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2008

समान संसाधन

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
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Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
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ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.
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Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
द्वारा: McNeill, L, और अन्य
प्रकाशित: (2005)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
द्वारा: Horita, S, और अन्य
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Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
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Structural basis of prolyl hydroxylase domain inhibition by Molidustat
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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
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Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
द्वारा: Holt-Martyn, J, और अन्य
प्रकाशित: (2019)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
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Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
द्वारा: Chan, M, और अन्य
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Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
द्वारा: Lancaster, D, और अन्य
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The use of dioxygen by HIF prolyl hydroxylase (PHD1).
द्वारा: McNeill, L, और अन्य
प्रकाशित: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
द्वारा: Schlemminger, I, और अन्य
प्रकाशित: (2003)

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
द्वारा: Ehrismann, D, और अन्य
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द्वारा: Langley, G, और अन्य
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Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
द्वारा: Domene, C, और अन्य
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Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
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Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
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