Parallel nuclear magnetic resonance spectroscopy
Nuclear magnetic resonance (NMR) spectroscopy is a principal analytical technique used for the structure elucidation of molecules. This Primer covers different approaches to accelerate data acquisition and increase sensitivity of NMR measurements through parallelization, enabled by hardware design a...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2021
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| _version_ | 1797089405203120128 |
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| author | Kupče, Ē Frydman, L Webb, AG Yong, JRJ Claridge, TDW |
| author_facet | Kupče, Ē Frydman, L Webb, AG Yong, JRJ Claridge, TDW |
| author_sort | Kupče, Ē |
| collection | OXFORD |
| description | Nuclear magnetic resonance (NMR) spectroscopy is a principal analytical technique used for the structure elucidation of molecules. This Primer covers different approaches to accelerate data acquisition and increase sensitivity of NMR measurements through parallelization, enabled by hardware design and/or pulse sequence development. Starting with hardware-based methods, we discuss coupling multiple detectors to multiple samples so each detector/sample combination provides unique information. We then cover spatio-temporal encoding, which uses magnetic field gradients and frequency-selective manipulations to parallelize multidimensional acquisition and compress it into a single shot. We also consider the parallel manipulation of different magnetization reservoirs within a sample to yield new, information-rich pulse schemes using either homonuclear or multinuclear detection. The Experimentation section describes the set-up of parallel NMR techniques. Practical examples revealing improvements in speed and sensitivity offered by the parallel methods are demonstrated in Results. Examples of use of parallelization in small-molecule analysis are discussed in Applications, with experimental constraints addressed under the Limitations and optimizations and Reproducibility and data deposition sections. The most promising future developments are considered in the Outlook, where the largest gains are expected to emerge once the discussed techniques are combined. |
| first_indexed | 2024-03-07T03:03:41Z |
| format | Journal article |
| id | oxford-uuid:b1ccbb41-25df-4c39-b91a-3753da881e98 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:03:41Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:b1ccbb41-25df-4c39-b91a-3753da881e982022-03-27T04:06:51ZParallel nuclear magnetic resonance spectroscopyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b1ccbb41-25df-4c39-b91a-3753da881e98EnglishSymplectic ElementsSpringer Nature2021Kupče, ĒFrydman, LWebb, AGYong, JRJClaridge, TDWNuclear magnetic resonance (NMR) spectroscopy is a principal analytical technique used for the structure elucidation of molecules. This Primer covers different approaches to accelerate data acquisition and increase sensitivity of NMR measurements through parallelization, enabled by hardware design and/or pulse sequence development. Starting with hardware-based methods, we discuss coupling multiple detectors to multiple samples so each detector/sample combination provides unique information. We then cover spatio-temporal encoding, which uses magnetic field gradients and frequency-selective manipulations to parallelize multidimensional acquisition and compress it into a single shot. We also consider the parallel manipulation of different magnetization reservoirs within a sample to yield new, information-rich pulse schemes using either homonuclear or multinuclear detection. The Experimentation section describes the set-up of parallel NMR techniques. Practical examples revealing improvements in speed and sensitivity offered by the parallel methods are demonstrated in Results. Examples of use of parallelization in small-molecule analysis are discussed in Applications, with experimental constraints addressed under the Limitations and optimizations and Reproducibility and data deposition sections. The most promising future developments are considered in the Outlook, where the largest gains are expected to emerge once the discussed techniques are combined. |
| spellingShingle | Kupče, Ē Frydman, L Webb, AG Yong, JRJ Claridge, TDW Parallel nuclear magnetic resonance spectroscopy |
| title | Parallel nuclear magnetic resonance spectroscopy |
| title_full | Parallel nuclear magnetic resonance spectroscopy |
| title_fullStr | Parallel nuclear magnetic resonance spectroscopy |
| title_full_unstemmed | Parallel nuclear magnetic resonance spectroscopy |
| title_short | Parallel nuclear magnetic resonance spectroscopy |
| title_sort | parallel nuclear magnetic resonance spectroscopy |
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