The genetic relationship between handedness and neurodevelopmental disorders
Handedness and brain asymmetry have been linked to neurodevelopmental disorders such as dyslexia and schizophrenia. The genetic nature of this correlation is not understood. Recent discoveries have shown handedness is determined in part by the biological pathways that establish left/right (LR) body...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2014
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| _version_ | 1826291797273346048 |
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| author | Brandler, W Paracchini, S |
| author_facet | Brandler, W Paracchini, S |
| author_sort | Brandler, W |
| collection | OXFORD |
| description | Handedness and brain asymmetry have been linked to neurodevelopmental disorders such as dyslexia and schizophrenia. The genetic nature of this correlation is not understood. Recent discoveries have shown handedness is determined in part by the biological pathways that establish left/right (LR) body asymmetry during development. Cilia play a key role in this process, and candidate genes for dyslexia have also been recently shown to be involved in cilia formation. Defective cilia result not only in LR body asymmetry phenotypes but also brain midline phenotypes such as an absent corpus callosum. These findings suggest that the mechanisms for establishing LR asymmetry in the body are reused for brain midline development, which in turn influences traits such as handedness and reading ability. |
| first_indexed | 2024-03-07T03:04:51Z |
| format | Journal article |
| id | oxford-uuid:b226adb9-4240-42f2-ba13-ade13ee85078 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:04:51Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:b226adb9-4240-42f2-ba13-ade13ee850782022-03-27T04:09:41ZThe genetic relationship between handedness and neurodevelopmental disordersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b226adb9-4240-42f2-ba13-ade13ee85078Genetics (medical sciences)NeuroscienceEnglishOxford University Research Archive - ValetElsevier2014Brandler, WParacchini, SHandedness and brain asymmetry have been linked to neurodevelopmental disorders such as dyslexia and schizophrenia. The genetic nature of this correlation is not understood. Recent discoveries have shown handedness is determined in part by the biological pathways that establish left/right (LR) body asymmetry during development. Cilia play a key role in this process, and candidate genes for dyslexia have also been recently shown to be involved in cilia formation. Defective cilia result not only in LR body asymmetry phenotypes but also brain midline phenotypes such as an absent corpus callosum. These findings suggest that the mechanisms for establishing LR asymmetry in the body are reused for brain midline development, which in turn influences traits such as handedness and reading ability. |
| spellingShingle | Genetics (medical sciences) Neuroscience Brandler, W Paracchini, S The genetic relationship between handedness and neurodevelopmental disorders |
| title | The genetic relationship between handedness and neurodevelopmental disorders |
| title_full | The genetic relationship between handedness and neurodevelopmental disorders |
| title_fullStr | The genetic relationship between handedness and neurodevelopmental disorders |
| title_full_unstemmed | The genetic relationship between handedness and neurodevelopmental disorders |
| title_short | The genetic relationship between handedness and neurodevelopmental disorders |
| title_sort | genetic relationship between handedness and neurodevelopmental disorders |
| topic | Genetics (medical sciences) Neuroscience |
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