Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salv...
Main Authors: | Wang, L, Ko, E, Gilchrist, J, Pittman, K, Rautanen, A, Pirinen, M, Thompson, J, Dubois, L, Langley, R, Jaslow, S, Salinas, R, Rouse, D, Moseley, M, Mwarumba, S, Njuguna, P, Mturi, N, Wellcome Trust Case Control Consortium 2, Kenyan Bacteraemia Study Group, Williams, T, Scott, J, Hill, A, Woods, C, Ginsburg, G, Tsalik, E, Ko, D |
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Format: | Journal article |
Language: | English |
Published: |
American Association for the Advancement of Science
2017
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