Organ-specific collagen expression: implications for renal disease.
Chronic kidney disease is characterized by progressive accumulation of extracellular matrix and scarring, leading to the loss of kidney function. Excess deposition of the collagen family of proteins is the hallmark of kidney fibrosis. In this review, we survey the collagens that are associated with...
| Príomhchruthaitheoirí: | , , |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2006
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| _version_ | 1826291809940144128 |
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| author | Alexakis, C Maxwell, P Bou-Gharios, G |
| author_facet | Alexakis, C Maxwell, P Bou-Gharios, G |
| author_sort | Alexakis, C |
| collection | OXFORD |
| description | Chronic kidney disease is characterized by progressive accumulation of extracellular matrix and scarring, leading to the loss of kidney function. Excess deposition of the collagen family of proteins is the hallmark of kidney fibrosis. In this review, we survey the collagens that are associated with renal disease and we highlight the use of a transgenic approach to identify cis-acting sequences in the collagen type I promoter which are capable of directing collagen type I expression specifically in the kidney. Ultimately it may be possible to use this approach to halt the accumulation of collagen selectively in this organ. |
| first_indexed | 2024-03-07T03:05:03Z |
| format | Journal article |
| id | oxford-uuid:b236eada-3096-4270-9cb2-6b2ea8fb21f7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:05:03Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:b236eada-3096-4270-9cb2-6b2ea8fb21f72022-03-27T04:10:10ZOrgan-specific collagen expression: implications for renal disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b236eada-3096-4270-9cb2-6b2ea8fb21f7EnglishSymplectic Elements at Oxford2006Alexakis, CMaxwell, PBou-Gharios, GChronic kidney disease is characterized by progressive accumulation of extracellular matrix and scarring, leading to the loss of kidney function. Excess deposition of the collagen family of proteins is the hallmark of kidney fibrosis. In this review, we survey the collagens that are associated with renal disease and we highlight the use of a transgenic approach to identify cis-acting sequences in the collagen type I promoter which are capable of directing collagen type I expression specifically in the kidney. Ultimately it may be possible to use this approach to halt the accumulation of collagen selectively in this organ. |
| spellingShingle | Alexakis, C Maxwell, P Bou-Gharios, G Organ-specific collagen expression: implications for renal disease. |
| title | Organ-specific collagen expression: implications for renal disease. |
| title_full | Organ-specific collagen expression: implications for renal disease. |
| title_fullStr | Organ-specific collagen expression: implications for renal disease. |
| title_full_unstemmed | Organ-specific collagen expression: implications for renal disease. |
| title_short | Organ-specific collagen expression: implications for renal disease. |
| title_sort | organ specific collagen expression implications for renal disease |
| work_keys_str_mv | AT alexakisc organspecificcollagenexpressionimplicationsforrenaldisease AT maxwellp organspecificcollagenexpressionimplicationsforrenaldisease AT boughariosg organspecificcollagenexpressionimplicationsforrenaldisease |