Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand.
A small but variable subgroup of patients with myasthenia gravis (MG) who have antibodies to muscle-specific kinase (MuSKAb-MG) can present with distinct phenotypes and are often treatment-resistant. The prevalence, clinical phenotypes and outcomes of treatment of patients with MuSKAb-MG in Thailand...
| Автори: | , , , , , , |
|---|---|
| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
2013
|
| _version_ | 1826291818265837568 |
|---|---|
| author | Witoonpanich, R Dejthevaporn, C Pulkes, T Tunlayadechanont, S Boonkongchuen, P Pongpakdee, S Vincent, A |
| author_facet | Witoonpanich, R Dejthevaporn, C Pulkes, T Tunlayadechanont, S Boonkongchuen, P Pongpakdee, S Vincent, A |
| author_sort | Witoonpanich, R |
| collection | OXFORD |
| description | A small but variable subgroup of patients with myasthenia gravis (MG) who have antibodies to muscle-specific kinase (MuSKAb-MG) can present with distinct phenotypes and are often treatment-resistant. The prevalence, clinical phenotypes and outcomes of treatment of patients with MuSKAb-MG in Thailand were determined. Eight (16.3%) of the 49 patients with generalized MG who were negative for acetylcholine receptor antibodies (AChRAb) were positive for muscle-specific kinase antibodies. Most patients had predominant oculobulbar features and respiratory failure occurred in three. At follow up, three out of the seven patients who underwent thymectomy were in complete stable remission and four had improved and were on reduced immunosuppression medication, suggesting a possible benefit of thymectomy. |
| first_indexed | 2024-03-07T03:05:10Z |
| format | Journal article |
| id | oxford-uuid:b23f778c-990f-4a6a-86a7-d60af15b96e6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:05:10Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:b23f778c-990f-4a6a-86a7-d60af15b96e62022-03-27T04:10:28ZPrevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b23f778c-990f-4a6a-86a7-d60af15b96e6EnglishSymplectic Elements at Oxford2013Witoonpanich, RDejthevaporn, CPulkes, TTunlayadechanont, SBoonkongchuen, PPongpakdee, SVincent, AA small but variable subgroup of patients with myasthenia gravis (MG) who have antibodies to muscle-specific kinase (MuSKAb-MG) can present with distinct phenotypes and are often treatment-resistant. The prevalence, clinical phenotypes and outcomes of treatment of patients with MuSKAb-MG in Thailand were determined. Eight (16.3%) of the 49 patients with generalized MG who were negative for acetylcholine receptor antibodies (AChRAb) were positive for muscle-specific kinase antibodies. Most patients had predominant oculobulbar features and respiratory failure occurred in three. At follow up, three out of the seven patients who underwent thymectomy were in complete stable remission and four had improved and were on reduced immunosuppression medication, suggesting a possible benefit of thymectomy. |
| spellingShingle | Witoonpanich, R Dejthevaporn, C Pulkes, T Tunlayadechanont, S Boonkongchuen, P Pongpakdee, S Vincent, A Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand. |
| title | Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand. |
| title_full | Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand. |
| title_fullStr | Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand. |
| title_full_unstemmed | Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand. |
| title_short | Prevalence, clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle-specific kinase in Thailand. |
| title_sort | prevalence clinical features and treatment outcomes of patients with myasthenia gravis positive for antibodies to muscle specific kinase in thailand |
| work_keys_str_mv | AT witoonpanichr prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand AT dejthevapornc prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand AT pulkest prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand AT tunlayadechanonts prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand AT boonkongchuenp prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand AT pongpakdees prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand AT vincenta prevalenceclinicalfeaturesandtreatmentoutcomesofpatientswithmyastheniagravispositiveforantibodiestomusclespecifickinaseinthailand |