Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.
Dehydroquinate synthase (DHQS) has long been regarded as a catalytic marvel because of its ability to perform several consecutive chemical reactions in one active site. There has been considerable debate as to whether DHQS is actively involved in all these steps, or whether several steps occur spont...
Главные авторы: | Carpenter, E, Hawkins, A, Frost, J, Brown, K |
---|---|
Формат: | Journal article |
Язык: | English |
Опубликовано: |
1998
|
Схожие документы
-
Multistep catalysis dehydroquinate synthase.
по: Brown, K, и др.
Опубликовано: (2000) -
Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase.
по: Nichols, C, и др.
Опубликовано: (2001) -
Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.
по: Park, A, и др.
Опубликовано: (2004) -
Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase.
по: Nichols, C, и др.
Опубликовано: (2003) -
Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
по: Nichols, C, и др.
Опубликовано: (2004)