Enantioselective total synthesis of (+)-incargranine A enabled by bifunctional iminophosphorane and iridium catalysis

Herein we report the first enantioselective total synthesis of (+)-incargranine A, in nine steps. The total synthesis was enabled by an enantioselective intramolecular organocatalysed desymmetrising Michael addition of a malonamate ester to a linked dienone substrate that established pivotal stereoc...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Miller, AAM, Biallas, P, Shennan, BDA, Dixon, DJ
Formaat: Journal article
Taal:English
Gepubliceerd in: Wiley 2023