The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2016
|
| _version_ | 1826291896924766208 |
|---|---|
| author | Lupton, MK Strike, L Hansell, NK Wen, W Mather, KA Armstrong, NJ Thalamuthu, A McMahon, KL De Zubicaray, GI Assareh, AA Simmons, A Proitsi, P Powell, JF Montgomery, GW Hibar, DP Westman, E Tsolaki, M Kloszewska, I Soininen, H Mecocci, P Velas, B Lovestone, S Brodaty, H Ames, D Trollor, JN Martin, NG Thompson, PM Sachdev, PS Wright, MJ |
| author_facet | Lupton, MK Strike, L Hansell, NK Wen, W Mather, KA Armstrong, NJ Thalamuthu, A McMahon, KL De Zubicaray, GI Assareh, AA Simmons, A Proitsi, P Powell, JF Montgomery, GW Hibar, DP Westman, E Tsolaki, M Kloszewska, I Soininen, H Mecocci, P Velas, B Lovestone, S Brodaty, H Ames, D Trollor, JN Martin, NG Thompson, PM Sachdev, PS Wright, MJ |
| author_sort | Lupton, MK |
| collection | OXFORD |
| description | Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16–30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults. |
| first_indexed | 2024-03-07T03:06:23Z |
| format | Journal article |
| id | oxford-uuid:b2accfef-4776-4ca3-a4eb-b36a9fc4b775 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:06:23Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:b2accfef-4776-4ca3-a4eb-b36a9fc4b7752022-03-27T04:13:30ZThe effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volumeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b2accfef-4776-4ca3-a4eb-b36a9fc4b775EnglishSymplectic Elements at OxfordElsevier2016Lupton, MKStrike, LHansell, NKWen, WMather, KAArmstrong, NJThalamuthu, AMcMahon, KLDe Zubicaray, GIAssareh, AASimmons, AProitsi, PPowell, JFMontgomery, GWHibar, DPWestman, ETsolaki, MKloszewska, ISoininen, HMecocci, PVelas, BLovestone, SBrodaty, HAmes, DTrollor, JNMartin, NGThompson, PMSachdev, PSWright, MJReduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16–30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults. |
| spellingShingle | Lupton, MK Strike, L Hansell, NK Wen, W Mather, KA Armstrong, NJ Thalamuthu, A McMahon, KL De Zubicaray, GI Assareh, AA Simmons, A Proitsi, P Powell, JF Montgomery, GW Hibar, DP Westman, E Tsolaki, M Kloszewska, I Soininen, H Mecocci, P Velas, B Lovestone, S Brodaty, H Ames, D Trollor, JN Martin, NG Thompson, PM Sachdev, PS Wright, MJ The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume |
| title | The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume |
| title_full | The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume |
| title_fullStr | The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume |
| title_full_unstemmed | The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume |
| title_short | The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume |
| title_sort | effect of increased genetic risk for alzheimer s disease on hippocampal and amygdala volume |
| work_keys_str_mv | AT luptonmk theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT strikel theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT hansellnk theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT wenw theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT matherka theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT armstrongnj theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT thalamuthua theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT mcmahonkl theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT dezubicaraygi theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT assarehaa theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT simmonsa theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT proitsip theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT powelljf theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT montgomerygw theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT hibardp theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT westmane theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT tsolakim theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT kloszewskai theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT soininenh theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT mecoccip theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT velasb theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT lovestones theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT brodatyh theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT amesd theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT trollorjn theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT martinng theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT thompsonpm theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT sachdevps theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT wrightmj theeffectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT luptonmk effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT strikel effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT hansellnk effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT wenw effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT matherka effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT armstrongnj effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT thalamuthua effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT mcmahonkl effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT dezubicaraygi effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT assarehaa effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT simmonsa effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT proitsip effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT powelljf effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT montgomerygw effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT hibardp effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT westmane effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT tsolakim effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT kloszewskai effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT soininenh effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT mecoccip effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT velasb effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT lovestones effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT brodatyh effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT amesd effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT trollorjn effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT martinng effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT thompsonpm effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT sachdevps effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume AT wrightmj effectofincreasedgeneticriskforalzheimersdiseaseonhippocampalandamygdalavolume |