Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Select an isoform: Linking of cosubstrate and substrate binding sites enables highly selective inhibiton of isoforms of human histone lysine demethylases. The results should provide a basis for the development of potent and selective JmjC inhibitors, possibly suitable for clinical use. Copyright © 2...

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Váldodahkkit: Woon, E, Tumber, A, Kawamura, A, Hillringhaus, L, Ge, W, Rose, N, Ma, J, Chan, M, Walport, L, Che, K, Ng, S, Marsden, B, Oppermann, U, McDonough, M, Schofield, C
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2012

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