Development of copper-catalysed addition reactions to alkynes
<p>In this thesis, new copper-catalysed addition reactions to alkynes have been developed. The new methodologies exploit hydro-functionalisation to transform readily available starting materials into N-heterocycles and enol esters via addition of amides and acids to alkynes, respectively.</...
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| Format: | Thesis |
| Language: | English |
| Published: |
2019
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| Summary: | <p>In this thesis, new copper-catalysed addition reactions to alkynes have been
developed. The new methodologies exploit hydro-functionalisation to transform readily
available starting materials into N-heterocycles and enol esters via addition of amides and
acids to alkynes, respectively.</p>
<p><b>Chapter 1</b> is a literature review covering the transition metal-catalysed hydroamination
and hydro-oxycarbonylation of alkynes, and some of the well-known copper-catalysed
reactions.</p>
<p><b>Chapter 2</b> documents our new methodology on exploiting the copper-catalysed
hydroamination of terminal alkynes to synthesis 5-ylidenepyrrol-2(5H)-ones and
5-hydroxypyrrol-2(5H)-ones, using readily available α-keto amides and terminal alkynes.
A method towards the synthesis of asymmetric maleimides is also reported.</p> |
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