Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR.
Nerve growth factor (NGF) is the ligand for two unrelated cellular receptors, TrkA and p75(NTR), and acts as a mediator in the development and maintenance of the mammalian nervous system. Signaling through TrkA kinase domains promotes neuronal survival, whereas activation of the p75(NTR) "death...
Main Authors: | Aurikko, J, Ruotolo, B, Grossmann, J, Moncrieffe, M, Stephens, E, Leppänen, V, Robinson, C, Saarma, M, Bradshaw, R, Blundell, T |
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Format: | Journal article |
Language: | English |
Published: |
2005
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