Disassembly of intact multiprotein complexes in the gas phase.

Disassembly of intact multiprotein complexes in the gas phase.

The observation of multiprotein complexes by mass spectrometry formerly relied upon chemical cross-linking to maintain interactions. Recent technological developments have enabled the observation of intact macromolecular complexes without modification. These assemblies, with masses far in excess of...

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Bibliografische gegevens
Hoofdauteurs: Rostom, A, Robinson, C
Formaat: Journal article
Taal:English
Gepubliceerd in: 1999
Omschrijving
Samenvatting:The observation of multiprotein complexes by mass spectrometry formerly relied upon chemical cross-linking to maintain interactions. Recent technological developments have enabled the observation of intact macromolecular complexes without modification. These assemblies, with masses far in excess of those measured previously, can be examined through controlled dissociation in the mass spectrometer, revealing information about their subunit interactions and topology.

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