Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition
The value of readily available 2-C-methyl aldonic acids in short syntheses of carbon branched piperidines containing quaternary centers is demonstrated. The effect of the introduction of a 4-C-methyl group into piperidine imino sugar inhibitors of l-fucosidases and d-galactosidases is reported. © 20...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797089624126914560 |
|---|---|
| author | Hotchkiss, D Kato, A Odell, B Claridge, T Fleet, G |
| author_facet | Hotchkiss, D Kato, A Odell, B Claridge, T Fleet, G |
| author_sort | Hotchkiss, D |
| collection | OXFORD |
| description | The value of readily available 2-C-methyl aldonic acids in short syntheses of carbon branched piperidines containing quaternary centers is demonstrated. The effect of the introduction of a 4-C-methyl group into piperidine imino sugar inhibitors of l-fucosidases and d-galactosidases is reported. © 2007 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-07T03:06:43Z |
| format | Journal article |
| id | oxford-uuid:b2cae2ab-0735-4d03-8aff-411d561bc401 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:06:43Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:b2cae2ab-0735-4d03-8aff-411d561bc4012022-03-27T04:14:11ZHomochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibitionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b2cae2ab-0735-4d03-8aff-411d561bc401EnglishSymplectic Elements at Oxford2007Hotchkiss, DKato, AOdell, BClaridge, TFleet, GThe value of readily available 2-C-methyl aldonic acids in short syntheses of carbon branched piperidines containing quaternary centers is demonstrated. The effect of the introduction of a 4-C-methyl group into piperidine imino sugar inhibitors of l-fucosidases and d-galactosidases is reported. © 2007 Elsevier Ltd. All rights reserved. |
| spellingShingle | Hotchkiss, D Kato, A Odell, B Claridge, T Fleet, G Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition |
| title | Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition |
| title_full | Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition |
| title_fullStr | Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition |
| title_full_unstemmed | Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition |
| title_short | Homochiral carbon branched piperidines from carbon branched sugar lactones: 4-C-methyl-deoxyfuconojirimycin (DFJ) and its enantiomer - removal of glycosidase inhibition |
| title_sort | homochiral carbon branched piperidines from carbon branched sugar lactones 4 c methyl deoxyfuconojirimycin dfj and its enantiomer removal of glycosidase inhibition |
| work_keys_str_mv | AT hotchkissd homochiralcarbonbranchedpiperidinesfromcarbonbranchedsugarlactones4cmethyldeoxyfuconojirimycindfjanditsenantiomerremovalofglycosidaseinhibition AT katoa homochiralcarbonbranchedpiperidinesfromcarbonbranchedsugarlactones4cmethyldeoxyfuconojirimycindfjanditsenantiomerremovalofglycosidaseinhibition AT odellb homochiralcarbonbranchedpiperidinesfromcarbonbranchedsugarlactones4cmethyldeoxyfuconojirimycindfjanditsenantiomerremovalofglycosidaseinhibition AT claridget homochiralcarbonbranchedpiperidinesfromcarbonbranchedsugarlactones4cmethyldeoxyfuconojirimycindfjanditsenantiomerremovalofglycosidaseinhibition AT fleetg homochiralcarbonbranchedpiperidinesfromcarbonbranchedsugarlactones4cmethyldeoxyfuconojirimycindfjanditsenantiomerremovalofglycosidaseinhibition |